Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5.
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| Title: | Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5. |
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| Authors: | Sachs J; Bio-Pharmaceutical Chemistry and Molecular Pharmacology, Faculty of Applied Natural Sciences, Technische Hochschule Köln, Leverkusen, Germany., Döhl K; Institute of Biochemistry, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany., Weber A; Institute of Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf im Forschungszentrum Jülich, Jülich, Germany., Bonus M; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany., Ehlers F; Bio-Pharmaceutical Chemistry and Molecular Pharmacology, Faculty of Applied Natural Sciences, Technische Hochschule Köln, Leverkusen, Germany., Fleischer E; MicroCombiChem GmbH, Wiesbaden, Germany., Klinger A; MicroCombiChem GmbH, Wiesbaden, Germany., Gohlke H; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.; John von Neumann Institute for Computing, Jülich Supercomputing Centre and Institute for Complex Systems - Structural Biochemistry, Forschungszentrum Jülich GmbH, Jülich, Germany., Pietruszka J; Institute of Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf im Forschungszentrum Jülich, Jülich, Germany.; IBG-1: Biotechnology, Forschungszentrum Jülich, Jülich, Germany., Schmitt L; Institute of Biochemistry, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany., Teusch N; Bio-Pharmaceutical Chemistry and Molecular Pharmacology, Faculty of Applied Natural Sciences, Technische Hochschule Köln, Leverkusen, Germany. |
| Source: | Frontiers in pharmacology [Front Pharmacol] 2019 Apr 16; Vol. 10, pp. 400. Date of Electronic Publication: 2019 Apr 16 (Print Publication: 2019). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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