View in EDS HTML Full Text PDF Full Text

Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects.

Saved in:
Bibliographic Details
Title: Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects.
Authors: Klotz L; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany. luisa.klotz@ukmuenster.de., Eschborn M; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Lindner M; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Liebmann M; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Herold M; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Janoschka C; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Torres Garrido B; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Schulte-Mecklenbeck A; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Gross CC; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Breuer J; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Hundehege P; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Posevitz V; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Pignolet B; CRC-SEP, Neurosciences Department, Toulouse University Hospital and INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Université Toulouse III, 31300 Toulouse, France., Nebel G; University of Münster, Institute of Molecular Cell Biology, 48149 Münster, Germany., Glander S; University of Münster, Department of Genetic Epidemiology, 48149 Münster, Germany., Freise N; University of Münster, Department of Immunology, 48149 Münster, Germany., Austermann J; University of Münster, Department of Immunology, 48149 Münster, Germany., Wirth T; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Campbell GR; University of Edinburgh, Centre for Clinical Brain Sciences, EH8 9YL Edinburgh, UK., Schneider-Hohendorf T; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Eveslage M; University of Münster, Institute of Biostatistics and Clinical Research, 48149 Münster, Germany., Brassat D; CRC-SEP, Neurosciences Department, Toulouse University Hospital and INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Université Toulouse III, 31300 Toulouse, France., Schwab N; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Loser K; University Hospital Münster, Department of Dermatology, 48149 Münster, Germany., Roth J; University of Münster, Department of Immunology, 48149 Münster, Germany., Busch KB; University of Münster, Institute of Molecular Cell Biology, 48149 Münster, Germany., Stoll M; University of Münster, Department of Genetic Epidemiology, 48149 Münster, Germany.; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, 6229 ER Maastricht, Netherlands., Mahad DJ; University of Edinburgh, Centre for Clinical Brain Sciences, EH8 9YL Edinburgh, UK., Meuth SG; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany., Turner T; Sanofi Genzyme, Cambridge, MA 02142, USA., Bar-Or A; Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Wiendl H; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.; Brain and Mind Centre, Medical Faculty, University of Sydney, Sydney, Camperdown, NSW 2050, Australia.
Source: Science translational medicine [Sci Transl Med] 2019 May 01; Vol. 11 (490).
Publication Type: Clinical Trial, Phase III; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 31043571
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Klotz+L%22">Klotz L</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany. luisa.klotz@ukmuenster.de.<br /><searchLink fieldCode="AU" term="%22Eschborn+M%22">Eschborn M</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Lindner+M%22">Lindner M</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Liebmann+M%22">Liebmann M</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Herold+M%22">Herold M</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Janoschka+C%22">Janoschka C</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Torres+Garrido+B%22">Torres Garrido B</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Schulte-Mecklenbeck+A%22">Schulte-Mecklenbeck A</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Gross+CC%22">Gross CC</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Breuer+J%22">Breuer J</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Hundehege+P%22">Hundehege P</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Posevitz+V%22">Posevitz V</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Pignolet+B%22">Pignolet B</searchLink>; CRC-SEP, Neurosciences Department, Toulouse University Hospital and INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Université Toulouse III, 31300 Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Nebel+G%22">Nebel G</searchLink>; University of Münster, Institute of Molecular Cell Biology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Glander+S%22">Glander S</searchLink>; University of Münster, Department of Genetic Epidemiology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Freise+N%22">Freise N</searchLink>; University of Münster, Department of Immunology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Austermann+J%22">Austermann J</searchLink>; University of Münster, Department of Immunology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Wirth+T%22">Wirth T</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Campbell+GR%22">Campbell GR</searchLink>; University of Edinburgh, Centre for Clinical Brain Sciences, EH8 9YL Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Schneider-Hohendorf+T%22">Schneider-Hohendorf T</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Eveslage+M%22">Eveslage M</searchLink>; University of Münster, Institute of Biostatistics and Clinical Research, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Brassat+D%22">Brassat D</searchLink>; CRC-SEP, Neurosciences Department, Toulouse University Hospital and INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Université Toulouse III, 31300 Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Schwab+N%22">Schwab N</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Loser+K%22">Loser K</searchLink>; University Hospital Münster, Department of Dermatology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Roth+J%22">Roth J</searchLink>; University of Münster, Department of Immunology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Busch+KB%22">Busch KB</searchLink>; University of Münster, Institute of Molecular Cell Biology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Stoll+M%22">Stoll M</searchLink>; University of Münster, Department of Genetic Epidemiology, 48149 Münster, Germany.; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, 6229 ER Maastricht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Mahad+DJ%22">Mahad DJ</searchLink>; University of Edinburgh, Centre for Clinical Brain Sciences, EH8 9YL Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Meuth+SG%22">Meuth SG</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Turner+T%22">Turner T</searchLink>; Sanofi Genzyme, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Bar-Or+A%22">Bar-Or A</searchLink>; Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Wiendl+H%22">Wiendl H</searchLink>; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.; Brain and Mind Centre, Medical Faculty, University of Sydney, Sydney, Camperdown, NSW 2050, Australia.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2019 May 01; Vol. 11 (490).
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Clinical Trial, Phase III; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101505086 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1946-6242 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219466234%22">19466234 </searchLink><i>NLM ISO Abbreviation: </i>Sci Transl Med <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=31043571
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/scitranslmed.aao5563
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Klotz L
      – PersonEntity:
          Name:
            NameFull: Eschborn M
      – PersonEntity:
          Name:
            NameFull: Lindner M
      – PersonEntity:
          Name:
            NameFull: Liebmann M
      – PersonEntity:
          Name:
            NameFull: Herold M
      – PersonEntity:
          Name:
            NameFull: Janoschka C
      – PersonEntity:
          Name:
            NameFull: Torres Garrido B
      – PersonEntity:
          Name:
            NameFull: Schulte-Mecklenbeck A
      – PersonEntity:
          Name:
            NameFull: Gross CC
      – PersonEntity:
          Name:
            NameFull: Breuer J
      – PersonEntity:
          Name:
            NameFull: Hundehege P
      – PersonEntity:
          Name:
            NameFull: Posevitz V
      – PersonEntity:
          Name:
            NameFull: Pignolet B
      – PersonEntity:
          Name:
            NameFull: Nebel G
      – PersonEntity:
          Name:
            NameFull: Glander S
      – PersonEntity:
          Name:
            NameFull: Freise N
      – PersonEntity:
          Name:
            NameFull: Austermann J
      – PersonEntity:
          Name:
            NameFull: Wirth T
      – PersonEntity:
          Name:
            NameFull: Campbell GR
      – PersonEntity:
          Name:
            NameFull: Schneider-Hohendorf T
      – PersonEntity:
          Name:
            NameFull: Eveslage M
      – PersonEntity:
          Name:
            NameFull: Brassat D
      – PersonEntity:
          Name:
            NameFull: Schwab N
      – PersonEntity:
          Name:
            NameFull: Loser K
      – PersonEntity:
          Name:
            NameFull: Roth J
      – PersonEntity:
          Name:
            NameFull: Busch KB
      – PersonEntity:
          Name:
            NameFull: Stoll M
      – PersonEntity:
          Name:
            NameFull: Mahad DJ
      – PersonEntity:
          Name:
            NameFull: Meuth SG
      – PersonEntity:
          Name:
            NameFull: Turner T
      – PersonEntity:
          Name:
            NameFull: Bar-Or A
      – PersonEntity:
          Name:
            NameFull: Wiendl H
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: 2019 May 01
              Type: published
              Y: 2019
          Identifiers:
            – Type: issn-electronic
              Value: 1946-6242
          Numbering:
            – Type: volume
              Value: 11
            – Type: issue
              Value: 490
          Titles:
            – TitleFull: Science translational medicine
              Type: main
ResultId 1