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HNF4α pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer.

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Title: HNF4α pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer.
Authors: Xu C; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Ooi WF; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore, Singapore., Qamra A; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore, Singapore.; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore., Tan J; Laboratory of Cancer Epigenome, Department of Medical Sciences, National Cancer Centre, Singapore, Singapore.; State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China., Chua BY; Agency for Science Technology and Research, Genome Institute of Singapore, Singapore, Singapore., Ho SWT; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Das K; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Adam Isa ZF; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Li Z; Laboratory of Cancer Epigenome, Department of Medical Sciences, National Cancer Centre, Singapore, Singapore., Yao X; Institute of Molecular and Cell Biology, Singapore, Singapore., Yan T; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Xing M; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore., Huang KK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Lin JS; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore, Singapore., Nandi T; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore, Singapore., Tay ST; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Lee MH; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Tan ALK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Ong X; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore., Ashktorab H; Department of Medicine, Howard University, Washington, DC, USA., Smoot D; Department of Internal Medicine, Meharry Medical College, Nashville, Tennessee, USA., Li S; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Ng SC; Agency for Science Technology and Research, Genome Institute of Singapore, Singapore, Singapore., Teh BT; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.; Laboratory of Cancer Epigenome, Department of Medical Sciences, National Cancer Centre, Singapore, Singapore.; Institute of Molecular and Cell Biology, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tan P; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore, Singapore.; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore, Singapore.; Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore, Singapore.
Source: Gut [Gut] 2020 Feb; Vol. 69 (2), pp. 231-242. Date of Electronic Publication: 2019 May 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ooi+WF%22">Ooi WF</searchLink>; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Qamra+A%22">Qamra A</searchLink>; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore, Singapore.; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+J%22">Tan J</searchLink>; Laboratory of Cancer Epigenome, Department of Medical Sciences, National Cancer Centre, Singapore, Singapore.; State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Chua+BY%22">Chua BY</searchLink>; Agency for Science Technology and Research, Genome Institute of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ho+SWT%22">Ho SWT</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Das+K%22">Das K</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Adam+Isa+ZF%22">Adam Isa ZF</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Laboratory of Cancer Epigenome, Department of Medical Sciences, National Cancer Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yao+X%22">Yao X</searchLink>; Institute of Molecular and Cell Biology, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yan+T%22">Yan T</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Xing+M%22">Xing M</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Huang+KK%22">Huang KK</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lin+JS%22">Lin JS</searchLink>; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Nandi+T%22">Nandi T</searchLink>; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tay+ST%22">Tay ST</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+MH%22">Lee MH</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+ALK%22">Tan ALK</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ong+X%22">Ong X</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ashktorab+H%22">Ashktorab H</searchLink>; Department of Medicine, Howard University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Smoot+D%22">Smoot D</searchLink>; Department of Internal Medicine, Meharry Medical College, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+SC%22">Ng SC</searchLink>; Agency for Science Technology and Research, Genome Institute of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Teh+BT%22">Teh BT</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.; Laboratory of Cancer Epigenome, Department of Medical Sciences, National Cancer Centre, Singapore, Singapore.; Institute of Molecular and Cell Biology, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+P%22">Tan P</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore, Singapore.; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore, Singapore.; Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore, Singapore.
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        Value: 10.1136/gutjnl-2018-318025
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