Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia.

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Title: Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia.
Authors: Braun DJ; Sanders-Brown Center on Aging, University of Kentucky, 101 Sanders-Brown Bldg., 800 S. Limestone Street, Lexington, KY, 40536, USA., Bachstetter AD; Sanders-Brown Center on Aging, University of Kentucky, 101 Sanders-Brown Bldg., 800 S. Limestone Street, Lexington, KY, 40536, USA.; Department of Neuroscience, University of Kentucky, Lexington, KY, 40536, USA.; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY, 40536, USA., Sudduth TL; Sanders-Brown Center on Aging, University of Kentucky, 101 Sanders-Brown Bldg., 800 S. Limestone Street, Lexington, KY, 40536, USA.; Department of Physiology, University of Kentucky, Lexington, KY, 40536, USA., Wilcock DM; Sanders-Brown Center on Aging, University of Kentucky, 101 Sanders-Brown Bldg., 800 S. Limestone Street, Lexington, KY, 40536, USA.; Department of Physiology, University of Kentucky, Lexington, KY, 40536, USA., Watterson DM; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Van Eldik LJ; Sanders-Brown Center on Aging, University of Kentucky, 101 Sanders-Brown Bldg., 800 S. Limestone Street, Lexington, KY, 40536, USA. linda.vaneldik@uky.edu.; Department of Neuroscience, University of Kentucky, Lexington, KY, 40536, USA. linda.vaneldik@uky.edu.; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY, 40536, USA. linda.vaneldik@uky.edu.
Source: GeroScience [Geroscience] 2019 Oct; Vol. 41 (5), pp. 671-679. Date of Electronic Publication: 2019 May 19.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2509-2723
DOI:10.1007/s11357-019-00072-4