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Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer.

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Title: Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer.
Authors: Schmitt K; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany., Molfenter B; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany., Laureano NK; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.; Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Oral Pathology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil., Tawk B; Division of Molecular and Translational Radiation Oncology, Heidelberg Ion Therapy Center (HIT), Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg University Hospital, and Translational Radiation Oncology, German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany., Bieg M; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), and Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany., Hostench XP; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), and Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany., Weichenhan D; Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Ullrich ND; Institute of Physiology and Pathophysiology, Division of Cardiovascular Physiology, Heidelberg University, Heidelberg, Germany., Shang V; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany., Richter D; Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden, Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany., Stögbauer F; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Schroeder L; Division of Molecular Diagnostics of Oncogenic Infections, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany., de Bem Prunes B; Oral Pathology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil., Visioli F; Oral Pathology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil., Rados PV; Oral Pathology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil., Jou A; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.; Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ), Heidelberg, Germany., Plath M; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany., Federspil PA; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany., Thierauf J; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany., Döscher J; Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany., Weissinger SE; Institute of Pathology, University Hospital Ulm, Ulm, Germany., Hoffmann TK; Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany., Wagner S; Department of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, Giessen, Germany., Wittekindt C; Department of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, Giessen, Germany., Ishaque N; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), and Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany., Eils R; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), and Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany., Klussmann JP; Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany., Holzinger D; Division of Molecular Diagnostics of Oncogenic Infections, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany., Plass C; Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Abdollahi A; Division of Molecular and Translational Radiation Oncology, Heidelberg Ion Therapy Center (HIT), Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg University Hospital, and Translational Radiation Oncology, German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany., Freier K; Department of Oral and Maxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany., Weichert W; Institute of Pathology, Technical University Munich (TUM), and German Cancer Consortium (DKTK) partner site, Munich, Germany., Zaoui K; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany., Hess J; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.; Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Source: International journal of cancer [Int J Cancer] 2019 Dec 15; Vol. 145 (12), pp. 3299-3310. Date of Electronic Publication: 2019 Jun 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer.
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  Data: <searchLink fieldCode="AU" term="%22Schmitt+K%22">Schmitt K</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Molfenter+B%22">Molfenter B</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Laureano+NK%22">Laureano NK</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.; Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Oral Pathology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Tawk+B%22">Tawk B</searchLink>; Division of Molecular and Translational Radiation Oncology, Heidelberg Ion Therapy Center (HIT), Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg University Hospital, and Translational Radiation Oncology, German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bieg+M%22">Bieg M</searchLink>; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), and Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hostench+XP%22">Hostench XP</searchLink>; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), and Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Weichenhan+D%22">Weichenhan D</searchLink>; Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ullrich+ND%22">Ullrich ND</searchLink>; Institute of Physiology and Pathophysiology, Division of Cardiovascular Physiology, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Shang+V%22">Shang V</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Richter+D%22">Richter D</searchLink>; Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden, Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Stögbauer+F%22">Stögbauer F</searchLink>; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schroeder+L%22">Schroeder L</searchLink>; Division of Molecular Diagnostics of Oncogenic Infections, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22de+Bem+Prunes+B%22">de Bem Prunes B</searchLink>; Oral Pathology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Visioli+F%22">Visioli F</searchLink>; Oral Pathology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Rados+PV%22">Rados PV</searchLink>; Oral Pathology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Jou+A%22">Jou A</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.; Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Plath+M%22">Plath M</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Federspil+PA%22">Federspil PA</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Thierauf+J%22">Thierauf J</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Döscher+J%22">Döscher J</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Weissinger+SE%22">Weissinger SE</searchLink>; Institute of Pathology, University Hospital Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Hoffmann+TK%22">Hoffmann TK</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+S%22">Wagner S</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Wittekindt+C%22">Wittekindt C</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, University of Giessen, Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Ishaque+N%22">Ishaque N</searchLink>; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), and Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Eils+R%22">Eils R</searchLink>; Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), and Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Klussmann+JP%22">Klussmann JP</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Holzinger+D%22">Holzinger D</searchLink>; Division of Molecular Diagnostics of Oncogenic Infections, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Plass+C%22">Plass C</searchLink>; Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Abdollahi+A%22">Abdollahi A</searchLink>; Division of Molecular and Translational Radiation Oncology, Heidelberg Ion Therapy Center (HIT), Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg University Hospital, and Translational Radiation Oncology, German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Freier+K%22">Freier K</searchLink>; Department of Oral and Maxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Weichert+W%22">Weichert W</searchLink>; Institute of Pathology, Technical University Munich (TUM), and German Cancer Consortium (DKTK) partner site, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Zaoui+K%22">Zaoui K</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hess+J%22">Hess J</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.; Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ), Heidelberg, Germany.
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