A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology.
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| Title: | A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology. |
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| Authors: | Gerez JA; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland. juan.gerez@phys.chem.ethz.ch.; Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland., Prymaczok NC; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.; Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland., Rockenstein E; Department of Neurosciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA., Herrmann US; Institute of Neuropathology, University Hospital Zurich, Zurich CH-8091, Switzerland., Schwarz P; Institute of Neuropathology, University Hospital Zurich, Zurich CH-8091, Switzerland., Adame A; Department of Neurosciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA., Enchev RI; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland., Courtheoux T; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland., Boersema PJ; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland., Riek R; Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland., Peter M; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland., Aguzzi A; Institute of Neuropathology, University Hospital Zurich, Zurich CH-8091, Switzerland., Masliah E; Department of Neurosciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA., Picotti P; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland. |
| Source: | Science translational medicine [Sci Transl Med] 2019 Jun 05; Vol. 11 (495). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.aau6722 |
