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A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology.

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Title: A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology.
Authors: Gerez JA; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland. juan.gerez@phys.chem.ethz.ch.; Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland., Prymaczok NC; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.; Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland., Rockenstein E; Department of Neurosciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA., Herrmann US; Institute of Neuropathology, University Hospital Zurich, Zurich CH-8091, Switzerland., Schwarz P; Institute of Neuropathology, University Hospital Zurich, Zurich CH-8091, Switzerland., Adame A; Department of Neurosciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA., Enchev RI; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland., Courtheoux T; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland., Boersema PJ; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland., Riek R; Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland., Peter M; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland., Aguzzi A; Institute of Neuropathology, University Hospital Zurich, Zurich CH-8091, Switzerland., Masliah E; Department of Neurosciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA., Picotti P; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.
Source: Science translational medicine [Sci Transl Med] 2019 Jun 05; Vol. 11 (495).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology.
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  Data: <searchLink fieldCode="AU" term="%22Gerez+JA%22">Gerez JA</searchLink>; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland. juan.gerez@phys.chem.ethz.ch.; Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Prymaczok+NC%22">Prymaczok NC</searchLink>; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.; Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rockenstein+E%22">Rockenstein E</searchLink>; Department of Neurosciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Herrmann+US%22">Herrmann US</searchLink>; Institute of Neuropathology, University Hospital Zurich, Zurich CH-8091, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schwarz+P%22">Schwarz P</searchLink>; Institute of Neuropathology, University Hospital Zurich, Zurich CH-8091, Switzerland.<br /><searchLink fieldCode="AU" term="%22Adame+A%22">Adame A</searchLink>; Department of Neurosciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Enchev+RI%22">Enchev RI</searchLink>; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Courtheoux+T%22">Courtheoux T</searchLink>; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Boersema+PJ%22">Boersema PJ</searchLink>; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Riek+R%22">Riek R</searchLink>; Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Peter+M%22">Peter M</searchLink>; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Aguzzi+A%22">Aguzzi A</searchLink>; Institute of Neuropathology, University Hospital Zurich, Zurich CH-8091, Switzerland.<br /><searchLink fieldCode="AU" term="%22Masliah+E%22">Masliah E</searchLink>; Department of Neurosciences, University of California, San Diego, La Jolla, San Diego, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Picotti+P%22">Picotti P</searchLink>; Institute of Biochemistry, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.; Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, CH-8093 Zurich, Switzerland.
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