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Structural and functional consequences of the STAT5BN642H driver mutation.

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Title: Structural and functional consequences of the STAT5BN642H driver mutation.
Authors: de Araujo ED; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada., Erdogan F; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada., Neubauer HA; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.; Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria., Meneksedag-Erol D; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.; Department of Physics, University of Toronto, 60 St. George Street, Toronto, ON, M5S 1A7, Canada., Manaswiyoungkul P; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada., Eram MS; Dalriada Drug Discovery, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada., Seo HS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA., Qadree AK; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada., Israelian J; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada., Orlova A; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.; Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria., Suske T; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Pham HTT; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.; Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria., Boersma A; Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Tangermann S; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Kenner L; Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria.; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.; Clinical Institute of Pathology, Department for Experimental and Laboratory Animal Pathology, Medical University of Vienna, 1090, Vienna, Austria., Rülicke T; Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, 1210, Vienna, Austria., Dong A; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON, M5G 1L7, Canada., Ravichandran M; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON, M5G 1L7, Canada., Brown PJ; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON, M5G 1L7, Canada., Audette GF; Department of Chemistry, York University, 327C Life Sciences Building, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada., Rauscher S; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.; Department of Physics, University of Toronto, 60 St. George Street, Toronto, ON, M5S 1A7, Canada., Dhe-Paganon S; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. dhepag@crystal.harvard.edu.; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA. dhepag@crystal.harvard.edu., Moriggl R; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria. richard.moriggl@vetmeduni.ac.at.; Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria. richard.moriggl@vetmeduni.ac.at.; Medical University of Vienna, 1090, Vienna, Austria. richard.moriggl@vetmeduni.ac.at., Gunning PT; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada. patrick.gunning@utoronto.ca.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada. patrick.gunning@utoronto.ca.
Source: Nature communications [Nat Commun] 2019 Jun 07; Vol. 10 (1), pp. 2517. Date of Electronic Publication: 2019 Jun 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structural and functional consequences of the STAT5B<superscript>N642H</superscript> driver mutation.
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  Data: <searchLink fieldCode="AU" term="%22de+Araujo+ED%22">de Araujo ED</searchLink>; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.<br /><searchLink fieldCode="AU" term="%22Erdogan+F%22">Erdogan F</searchLink>; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.<br /><searchLink fieldCode="AU" term="%22Neubauer+HA%22">Neubauer HA</searchLink>; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.; Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Meneksedag-Erol+D%22">Meneksedag-Erol D</searchLink>; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.; Department of Physics, University of Toronto, 60 St. George Street, Toronto, ON, M5S 1A7, Canada.<br /><searchLink fieldCode="AU" term="%22Manaswiyoungkul+P%22">Manaswiyoungkul P</searchLink>; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.<br /><searchLink fieldCode="AU" term="%22Eram+MS%22">Eram MS</searchLink>; Dalriada Drug Discovery, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.<br /><searchLink fieldCode="AU" term="%22Seo+HS%22">Seo HS</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.<br /><searchLink fieldCode="AU" term="%22Qadree+AK%22">Qadree AK</searchLink>; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.<br /><searchLink fieldCode="AU" term="%22Israelian+J%22">Israelian J</searchLink>; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.<br /><searchLink fieldCode="AU" term="%22Orlova+A%22">Orlova A</searchLink>; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.; Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Suske+T%22">Suske T</searchLink>; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Pham+HTT%22">Pham HTT</searchLink>; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.; Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Boersma+A%22">Boersma A</searchLink>; Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Tangermann+S%22">Tangermann S</searchLink>; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kenner+L%22">Kenner L</searchLink>; Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria.; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.; Clinical Institute of Pathology, Department for Experimental and Laboratory Animal Pathology, Medical University of Vienna, 1090, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Rülicke+T%22">Rülicke T</searchLink>; Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, 1210, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Dong+A%22">Dong A</searchLink>; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON, M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Ravichandran+M%22">Ravichandran M</searchLink>; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON, M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Brown+PJ%22">Brown PJ</searchLink>; Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, ON, M5G 1L7, Canada.<br /><searchLink fieldCode="AU" term="%22Audette+GF%22">Audette GF</searchLink>; Department of Chemistry, York University, 327C Life Sciences Building, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada.<br /><searchLink fieldCode="AU" term="%22Rauscher+S%22">Rauscher S</searchLink>; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.; Department of Physics, University of Toronto, 60 St. George Street, Toronto, ON, M5S 1A7, Canada.<br /><searchLink fieldCode="AU" term="%22Dhe-Paganon+S%22">Dhe-Paganon S</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. dhepag@crystal.harvard.edu.; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA. dhepag@crystal.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Moriggl+R%22">Moriggl R</searchLink>; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210, Vienna, Austria. richard.moriggl@vetmeduni.ac.at.; Ludwig Boltzmann Institute for Cancer Research, 1090, Vienna, Austria. richard.moriggl@vetmeduni.ac.at.; Medical University of Vienna, 1090, Vienna, Austria. richard.moriggl@vetmeduni.ac.at.<br /><searchLink fieldCode="AU" term="%22Gunning+PT%22">Gunning PT</searchLink>; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada. patrick.gunning@utoronto.ca.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada. patrick.gunning@utoronto.ca.
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