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TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation.

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Title: TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation.
Authors: Chiramel AI; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA., Meyerson NR; Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA., McNally KL; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA., Broeckel RM; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA., Montoya VR; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA., Méndez-Solís O; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA., Robertson SJ; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA., Sturdevant GL; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA., Lubick KJ; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA., Nair V; Research Technology Branch, RML, NIAID, NIH, Hamilton, MT 59840, USA., Youseff BH; Department of Medical Microbiology and Immunology, College of Medicine and Life Sciences, University of Toledo Health Science Campus, Toledo, OH 43606, USA., Ireland RM; Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, RML, NIAID, NIH, Hamilton, MT 59840, USA., Bosio CM; Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, RML, NIAID, NIH, Hamilton, MT 59840, USA., Kim K; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA., Luban J; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA., Hirsch VM; Laboratory of Molecular Microbiology, NIAID, Bethesda, MD 20892, USA., Taylor RT; Department of Medical Microbiology and Immunology, College of Medicine and Life Sciences, University of Toledo Health Science Campus, Toledo, OH 43606, USA., Bouamr F; Laboratory of Molecular Microbiology, NIAID, Bethesda, MD 20892, USA., Sawyer SL; Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA., Best SM; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA. Electronic address: sbest@niaid.nih.gov.
Source: Cell reports [Cell Rep] 2019 Jun 11; Vol. 27 (11), pp. 3269-3283.e6.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation.
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  Data: <searchLink fieldCode="AU" term="%22Chiramel+AI%22">Chiramel AI</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA.<br /><searchLink fieldCode="AU" term="%22Meyerson+NR%22">Meyerson NR</searchLink>; Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA.<br /><searchLink fieldCode="AU" term="%22McNally+KL%22">McNally KL</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA.<br /><searchLink fieldCode="AU" term="%22Broeckel+RM%22">Broeckel RM</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA.<br /><searchLink fieldCode="AU" term="%22Montoya+VR%22">Montoya VR</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA.<br /><searchLink fieldCode="AU" term="%22Méndez-Solís+O%22">Méndez-Solís O</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA.<br /><searchLink fieldCode="AU" term="%22Robertson+SJ%22">Robertson SJ</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA.<br /><searchLink fieldCode="AU" term="%22Sturdevant+GL%22">Sturdevant GL</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA.<br /><searchLink fieldCode="AU" term="%22Lubick+KJ%22">Lubick KJ</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA.<br /><searchLink fieldCode="AU" term="%22Nair+V%22">Nair V</searchLink>; Research Technology Branch, RML, NIAID, NIH, Hamilton, MT 59840, USA.<br /><searchLink fieldCode="AU" term="%22Youseff+BH%22">Youseff BH</searchLink>; Department of Medical Microbiology and Immunology, College of Medicine and Life Sciences, University of Toledo Health Science Campus, Toledo, OH 43606, USA.<br /><searchLink fieldCode="AU" term="%22Ireland+RM%22">Ireland RM</searchLink>; Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, RML, NIAID, NIH, Hamilton, MT 59840, USA.<br /><searchLink fieldCode="AU" term="%22Bosio+CM%22">Bosio CM</searchLink>; Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, RML, NIAID, NIH, Hamilton, MT 59840, USA.<br /><searchLink fieldCode="AU" term="%22Kim+K%22">Kim K</searchLink>; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.<br /><searchLink fieldCode="AU" term="%22Luban+J%22">Luban J</searchLink>; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.<br /><searchLink fieldCode="AU" term="%22Hirsch+VM%22">Hirsch VM</searchLink>; Laboratory of Molecular Microbiology, NIAID, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+RT%22">Taylor RT</searchLink>; Department of Medical Microbiology and Immunology, College of Medicine and Life Sciences, University of Toledo Health Science Campus, Toledo, OH 43606, USA.<br /><searchLink fieldCode="AU" term="%22Bouamr+F%22">Bouamr F</searchLink>; Laboratory of Molecular Microbiology, NIAID, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Sawyer+SL%22">Sawyer SL</searchLink>; Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA.<br /><searchLink fieldCode="AU" term="%22Best+SM%22">Best SM</searchLink>; Innate Immunity and Pathogenesis Section, Laboratory of Virology, Rocky Mountain Laboratories (RML), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA. Electronic address: sbest@niaid.nih.gov.
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