Genetic analyses of diverse populations improves discovery for complex traits.

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Title: Genetic analyses of diverse populations improves discovery for complex traits.
Authors: Wojcik GL; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA., Graff M; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Nishimura KK; Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Tao R; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Haessler J; Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Gignoux CR; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA.; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Highland HM; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Patel YM; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Sorokin EP; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA., Avery CL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Belbin GM; The Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bien SA; Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Cheng I; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA., Cullina S; The Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hodonsky CJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hu Y; Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Huckins LM; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jeff J; The Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Justice AE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kocarnik JM; Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Lim U; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA., Lin BM; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lu Y; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nelson SC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Park SL; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Poisner H; The Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Preuss MH; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Richard MA; Brown Foundation Institute for Molecular Medicine, The University of Texas Health Science Center, Houston, TX, USA., Schurmann C; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Hasso-Plattner-Institute for Digital Engineering, Digital Health Center, Potsdam, Germany.; Hasso-Plattner-Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Setiawan VW; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Sockell A; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA., Vahi K; Information Sciences Institute, University of Southern California, Marina del Rey, CA, USA., Verbanck M; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Vishnu A; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Walker RW; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Young KL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Zubair N; Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Acuña-Alonso V; Escuela Nacional de Antropologia e Historia, Mexico City, Mexico., Ambite JL; Information Sciences Institute, University of Southern California, Marina del Rey, CA, USA., Barnes KC; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Boerwinkle E; Human Genetics Center, School of Public Health, The University of Texas Health Science Center, Houston, TX, USA., Bottinger EP; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Hasso-Plattner-Institute for Digital Engineering, Digital Health Center, Potsdam, Germany.; Hasso-Plattner-Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bustamante CD; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA., Caberto C; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA., Canizales-Quinteros S; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Conomos MP; Department of Biostatistics, University of Washington, Seattle, WA, USA., Deelman E; Information Sciences Institute, University of Southern California, Marina del Rey, CA, USA., Do R; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Doheny K; Center for Inherited Disease Research, Johns Hopkins University, Baltimore, MD, USA., Fernández-Rhodes L; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA., Fornage M; Brown Foundation Institute for Molecular Medicine, The University of Texas Health Science Center, Houston, TX, USA., Hailu B; NIH National Institute on Minority Health and Health Disparities, Bethesda, MD, USA., Heiss G; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Henn BM; Department of Anthropology, University of California Davis, Davis, CA, USA., Hindorff LA; NIH National Human Genome Research Institute, Bethesda, MD, USA., Jackson RD; Center for Clinical and Translational Science, Ohio State Medical Center, Columbus, OH, USA., Laurie CA; Department of Biostatistics, University of Washington, Seattle, WA, USA., Laurie CC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Li Y; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.; Cancer Prevention Institute of California, Fremont, CA, USA., Lin DY; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Moreno-Estrada A; National Laboratory of Genomics for Biodiversity (UGA-LANGEBIO), Irapuato, Mexico., Nadkarni G; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Norman PJ; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Pooler LC; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Reiner AP; Department of Biostatistics, University of Washington, Seattle, WA, USA., Romm J; Center for Inherited Disease Research, Johns Hopkins University, Baltimore, MD, USA., Sabatti C; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA., Sandoval K; National Laboratory of Genomics for Biodiversity (UGA-LANGEBIO), Irapuato, Mexico., Sheng X; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Stahl EA; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Stram DO; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Thornton TA; Department of Biostatistics, University of Washington, Seattle, WA, USA., Wassel CL; College of Medicine, University of Vermont, Burlington, VT, USA., Wilkens LR; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA., Winkler CA; Basic Science Program, Frederick National Laboratory, Frederick, MD, USA., Yoneyama S; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Buyske S; Department of Statistics, Rutgers University, New Brunswick, NJ, USA., Haiman CA; Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Kooperberg C; Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Le Marchand L; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA., Loos RJF; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Matise TC; Department of Genetics, Rutgers University, New Brunswick, NJ, USA., North KE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Peters U; Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Kenny EE; The Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eimear.kenny@mssm.edu.; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eimear.kenny@mssm.edu.; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eimear.kenny@mssm.edu.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eimear.kenny@mssm.edu., Carlson CS; Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. ccarlson@fredhutch.org.
Source: Nature [Nature] 2019 Jun; Vol. 570 (7762), pp. 514-518. Date of Electronic Publication: 2019 Jun 19.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-019-1310-4