A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor.
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| Title: | A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor. |
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| Authors: | Fallacara AL; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. al.fallacara@gmail.com., Zamperini C; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. claudiozamperini@yahoo.it.; Lead Discovery Siena S.r.l., via Vittorio Alfieri 31, Castelnuovo Berardenga, 53019 Siena, Italy. claudiozamperini@yahoo.it., Podolski-Renić A; Department of Neurobiology, Institute for Biological Research 'Siniša Stanković' (IBISS), University of Belgrade, 11060 Belgrade (RS), Serbia. ana.podolski@ibiss.bg.ac.rs., Dinić J; Department of Neurobiology, Institute for Biological Research 'Siniša Stanković' (IBISS), University of Belgrade, 11060 Belgrade (RS), Serbia. jelena.dinic@ibiss.bg.ac.rs., Stanković T; Department of Neurobiology, Institute for Biological Research 'Siniša Stanković' (IBISS), University of Belgrade, 11060 Belgrade (RS), Serbia. tijana.andjelkovic@ibiss.bg.ac.rs., Stepanović M; Department of Neurobiology, Institute for Biological Research 'Siniša Stanković' (IBISS), University of Belgrade, 11060 Belgrade (RS), Serbia. marija.stepanovic@ibiss.bg.ac.rs., Mancini A; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. arianna.mancini3@gmail.com.; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy. arianna.mancini3@gmail.com., Rango E; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. rango.enrico@gmail.com., Iovenitti G; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. giulia.iovenitti@unisi.it., Molinari A; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. molinari.a2@gmail.com., Bugli F; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, 00168 Rome, Italy. francesca.bugli@unicatt.it.; Istituto di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. francesca.bugli@unicatt.it., Sanguinetti M; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, 00168 Rome, Italy. maurizio.sanguinetti@unicatt.it.; Istituto di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. maurizio.sanguinetti@unicatt.it., Torelli R; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, 00168 Rome, Italy. torelliric@yahoo.it.; Istituto di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. torelliric@yahoo.it., Martini M; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, 00168 Rome, Italy. maurizio.martini@unicatt.it.; Istituto di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. maurizio.martini@unicatt.it., Maccari L; Lead Discovery Siena S.r.l., via Vittorio Alfieri 31, Castelnuovo Berardenga, 53019 Siena, Italy. l.maccari@leaddiscoverysiena.it., Valoti M; Dipartimento Scienze della Vita, Università degli Studi di Siena, 53100 Siena, Italy. massimo.valoti@unisi.it., Dreassi E; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. elena.dreassi@unisi.it., Botta M; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. botta.maurizio@gmail.com.; Lead Discovery Siena S.r.l., via Vittorio Alfieri 31, Castelnuovo Berardenga, 53019 Siena, Italy. botta.maurizio@gmail.com., Pešić M; Department of Neurobiology, Institute for Biological Research 'Siniša Stanković' (IBISS), University of Belgrade, 11060 Belgrade (RS), Serbia. camala@ibiss.bg.ac.rs., Schenone S; Department of Pharmacy, Università degli Studi di Genova, 16132 Genova, Italy. schenone@difar.unige.it. |
| Source: | Cancers [Cancers (Basel)] 2019 Jun 19; Vol. 11 (6). Date of Electronic Publication: 2019 Jun 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 31248184 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Fallacara+AL%22">Fallacara AL</searchLink>; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. al.fallacara@gmail.com.<br /><searchLink fieldCode="AU" term="%22Zamperini+C%22">Zamperini C</searchLink>; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. claudiozamperini@yahoo.it.; Lead Discovery Siena S.r.l., via Vittorio Alfieri 31, Castelnuovo Berardenga, 53019 Siena, Italy. claudiozamperini@yahoo.it.<br /><searchLink fieldCode="AU" term="%22Podolski-Renić+A%22">Podolski-Renić A</searchLink>; Department of Neurobiology, Institute for Biological Research 'Siniša Stanković' (IBISS), University of Belgrade, 11060 Belgrade (RS), Serbia. ana.podolski@ibiss.bg.ac.rs.<br /><searchLink fieldCode="AU" term="%22Dinić+J%22">Dinić J</searchLink>; Department of Neurobiology, Institute for Biological Research 'Siniša Stanković' (IBISS), University of Belgrade, 11060 Belgrade (RS), Serbia. jelena.dinic@ibiss.bg.ac.rs.<br /><searchLink fieldCode="AU" term="%22Stanković+T%22">Stanković T</searchLink>; Department of Neurobiology, Institute for Biological Research 'Siniša Stanković' (IBISS), University of Belgrade, 11060 Belgrade (RS), Serbia. tijana.andjelkovic@ibiss.bg.ac.rs.<br /><searchLink fieldCode="AU" term="%22Stepanović+M%22">Stepanović M</searchLink>; Department of Neurobiology, Institute for Biological Research 'Siniša Stanković' (IBISS), University of Belgrade, 11060 Belgrade (RS), Serbia. marija.stepanovic@ibiss.bg.ac.rs.<br /><searchLink fieldCode="AU" term="%22Mancini+A%22">Mancini A</searchLink>; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. arianna.mancini3@gmail.com.; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy. arianna.mancini3@gmail.com.<br /><searchLink fieldCode="AU" term="%22Rango+E%22">Rango E</searchLink>; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. rango.enrico@gmail.com.<br /><searchLink fieldCode="AU" term="%22Iovenitti+G%22">Iovenitti G</searchLink>; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. giulia.iovenitti@unisi.it.<br /><searchLink fieldCode="AU" term="%22Molinari+A%22">Molinari A</searchLink>; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. molinari.a2@gmail.com.<br /><searchLink fieldCode="AU" term="%22Bugli+F%22">Bugli F</searchLink>; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, 00168 Rome, Italy. francesca.bugli@unicatt.it.; Istituto di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. francesca.bugli@unicatt.it.<br /><searchLink fieldCode="AU" term="%22Sanguinetti+M%22">Sanguinetti M</searchLink>; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, 00168 Rome, Italy. maurizio.sanguinetti@unicatt.it.; Istituto di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. maurizio.sanguinetti@unicatt.it.<br /><searchLink fieldCode="AU" term="%22Torelli+R%22">Torelli R</searchLink>; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, 00168 Rome, Italy. torelliric@yahoo.it.; Istituto di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. torelliric@yahoo.it.<br /><searchLink fieldCode="AU" term="%22Martini+M%22">Martini M</searchLink>; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, 00168 Rome, Italy. maurizio.martini@unicatt.it.; Istituto di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. maurizio.martini@unicatt.it.<br /><searchLink fieldCode="AU" term="%22Maccari+L%22">Maccari L</searchLink>; Lead Discovery Siena S.r.l., via Vittorio Alfieri 31, Castelnuovo Berardenga, 53019 Siena, Italy. l.maccari@leaddiscoverysiena.it.<br /><searchLink fieldCode="AU" term="%22Valoti+M%22">Valoti M</searchLink>; Dipartimento Scienze della Vita, Università degli Studi di Siena, 53100 Siena, Italy. massimo.valoti@unisi.it.<br /><searchLink fieldCode="AU" term="%22Dreassi+E%22">Dreassi E</searchLink>; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. elena.dreassi@unisi.it.<br /><searchLink fieldCode="AU" term="%22Botta+M%22">Botta M</searchLink>; Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, 53100 Siena, Italy. botta.maurizio@gmail.com.; Lead Discovery Siena S.r.l., via Vittorio Alfieri 31, Castelnuovo Berardenga, 53019 Siena, Italy. botta.maurizio@gmail.com.<br /><searchLink fieldCode="AU" term="%22Pešić+M%22">Pešić M</searchLink>; Department of Neurobiology, Institute for Biological Research 'Siniša Stanković' (IBISS), University of Belgrade, 11060 Belgrade (RS), Serbia. camala@ibiss.bg.ac.rs.<br /><searchLink fieldCode="AU" term="%22Schenone+S%22">Schenone S</searchLink>; Department of Pharmacy, Università degli Studi di Genova, 16132 Genova, Italy. schenone@difar.unige.it. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101526829%22">Cancers</searchLink> [Cancers (Basel)] 2019 Jun 19; Vol. 11 (6). <i>Date of Electronic Publication: </i>2019 Jun 19. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22MDPI%22">MDPI </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101526829 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2072-6694 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220726694%22">20726694 </searchLink><i>NLM ISO Abbreviation: </i>Cancers (Basel) <i>Subsets: </i>PubMed not MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/cancers11060848 Languages: – Code: eng Text: English Titles: – TitleFull: A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fallacara AL – PersonEntity: Name: NameFull: Zamperini C – PersonEntity: Name: NameFull: Podolski-Renić A – PersonEntity: Name: NameFull: Dinić J – PersonEntity: Name: NameFull: Stanković T – PersonEntity: Name: NameFull: Stepanović M – PersonEntity: Name: NameFull: Mancini A – PersonEntity: Name: NameFull: Rango E – PersonEntity: Name: NameFull: Iovenitti G – PersonEntity: Name: NameFull: Molinari A – PersonEntity: Name: NameFull: Bugli F – PersonEntity: Name: NameFull: Sanguinetti M – PersonEntity: Name: NameFull: Torelli R – PersonEntity: Name: NameFull: Martini M – PersonEntity: Name: NameFull: Maccari L – PersonEntity: Name: NameFull: Valoti M – PersonEntity: Name: NameFull: Dreassi E – PersonEntity: Name: NameFull: Botta M – PersonEntity: Name: NameFull: Pešić M – PersonEntity: Name: NameFull: Schenone S IsPartOfRelationships: – BibEntity: Dates: – D: 19 M: 06 Text: 2019 Jun 19 Type: published Y: 2019 Identifiers: – Type: issn-print Value: 2072-6694 Numbering: – Type: volume Value: 11 – Type: issue Value: 6 Titles: – TitleFull: Cancers Type: main |
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