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Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness.

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Title: Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness.
Authors: Boileau M; Division of Experimental Medicine, McGill University and McGill University Heath Centre Research Institute, Montreal, H4A 3J1, QC, Canada., Shirinian M; Department of Experimental Pathology, Immunology, and Microbiology, American University of Beirut, Beirut, 1107 2020, Lebanon.; Department of Internal Medicine, American University of Beirut, Beirut, 1107 2020, Lebanon., Gayden T; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada., Harutyunyan AS; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada., Chen CCL; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada., Mikael LG; Department of Pediatrics, McGill University and McGill University Heath Centre Research Institute, Montreal, H4A 3J1, QC, Canada., Duncan HM; Division of Experimental Medicine, McGill University and McGill University Heath Centre Research Institute, Montreal, H4A 3J1, QC, Canada., Neumann AL; Research Institute of the McGill University Health Centre and McGill University, Montreal, H4A 3J1, QC, Canada., Arreba-Tutusaus P; Research Institute of the McGill University Health Centre and McGill University, Montreal, H4A 3J1, QC, Canada., De Jay N; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, H3T 1E2, QC, Canada., Zeinieh M; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada., Rossokhata K; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada., Zhang Y; Research Institute of the McGill University Health Centre and McGill University, Montreal, H4A 3J1, QC, Canada., Nikbakht H; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.; McGill University and Génome Québec Innovation Centre, Montreal, H3A 0G1, QC, Canada., Mouawad C; Department of Experimental Pathology, Immunology, and Microbiology, American University of Beirut, Beirut, 1107 2020, Lebanon., Massoud R; Department of Internal Medicine, American University of Beirut, Beirut, 1107 2020, Lebanon., Frey F; Department of Experimental Pathology, Immunology, and Microbiology, American University of Beirut, Beirut, 1107 2020, Lebanon., Nasr R; Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, 1107 2020, Lebanon., El Cheikh J; Department of Internal Medicine, American University of Beirut, Beirut, 1107 2020, Lebanon., El Sabban M; Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, 1107 2020, Lebanon., Kleinman CL; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, H3T 1E2, QC, Canada., Mahfouz R; Department of Pathology and Laboratory Medicine, American University of Beirut, Beirut, 1107 2020, Lebanon., Minden MD; Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, M5G 2C1, ON, Canada.; Department of Medicine, University of Toronto, Toronto, M5S 1A8, ON, Canada., Jabado N; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.; Department of Pediatrics, McGill University and McGill University Heath Centre Research Institute, Montreal, H4A 3J1, QC, Canada., Bazarbachi A; Department of Internal Medicine, American University of Beirut, Beirut, 1107 2020, Lebanon.; Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, 1107 2020, Lebanon., Eppert K; Department of Pediatrics, McGill University and McGill University Heath Centre Research Institute, Montreal, H4A 3J1, QC, Canada. kolja.eppert@mcgill.ca.
Source: Nature communications [Nat Commun] 2019 Jun 28; Vol. 10 (1), pp. 2891. Date of Electronic Publication: 2019 Jun 28.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness.
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  Data: <searchLink fieldCode="AU" term="%22Boileau+M%22">Boileau M</searchLink>; Division of Experimental Medicine, McGill University and McGill University Heath Centre Research Institute, Montreal, H4A 3J1, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Shirinian+M%22">Shirinian M</searchLink>; Department of Experimental Pathology, Immunology, and Microbiology, American University of Beirut, Beirut, 1107 2020, Lebanon.; Department of Internal Medicine, American University of Beirut, Beirut, 1107 2020, Lebanon.<br /><searchLink fieldCode="AU" term="%22Gayden+T%22">Gayden T</searchLink>; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Harutyunyan+AS%22">Harutyunyan AS</searchLink>; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Chen+CCL%22">Chen CCL</searchLink>; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Mikael+LG%22">Mikael LG</searchLink>; Department of Pediatrics, McGill University and McGill University Heath Centre Research Institute, Montreal, H4A 3J1, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Duncan+HM%22">Duncan HM</searchLink>; Division of Experimental Medicine, McGill University and McGill University Heath Centre Research Institute, Montreal, H4A 3J1, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Neumann+AL%22">Neumann AL</searchLink>; Research Institute of the McGill University Health Centre and McGill University, Montreal, H4A 3J1, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Arreba-Tutusaus+P%22">Arreba-Tutusaus P</searchLink>; Research Institute of the McGill University Health Centre and McGill University, Montreal, H4A 3J1, QC, Canada.<br /><searchLink fieldCode="AU" term="%22De+Jay+N%22">De Jay N</searchLink>; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, H3T 1E2, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Zeinieh+M%22">Zeinieh M</searchLink>; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Rossokhata+K%22">Rossokhata K</searchLink>; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Research Institute of the McGill University Health Centre and McGill University, Montreal, H4A 3J1, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Nikbakht+H%22">Nikbakht H</searchLink>; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.; McGill University and Génome Québec Innovation Centre, Montreal, H3A 0G1, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Mouawad+C%22">Mouawad C</searchLink>; Department of Experimental Pathology, Immunology, and Microbiology, American University of Beirut, Beirut, 1107 2020, Lebanon.<br /><searchLink fieldCode="AU" term="%22Massoud+R%22">Massoud R</searchLink>; Department of Internal Medicine, American University of Beirut, Beirut, 1107 2020, Lebanon.<br /><searchLink fieldCode="AU" term="%22Frey+F%22">Frey F</searchLink>; Department of Experimental Pathology, Immunology, and Microbiology, American University of Beirut, Beirut, 1107 2020, Lebanon.<br /><searchLink fieldCode="AU" term="%22Nasr+R%22">Nasr R</searchLink>; Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, 1107 2020, Lebanon.<br /><searchLink fieldCode="AU" term="%22El+Cheikh+J%22">El Cheikh J</searchLink>; Department of Internal Medicine, American University of Beirut, Beirut, 1107 2020, Lebanon.<br /><searchLink fieldCode="AU" term="%22El+Sabban+M%22">El Sabban M</searchLink>; Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, 1107 2020, Lebanon.<br /><searchLink fieldCode="AU" term="%22Kleinman+CL%22">Kleinman CL</searchLink>; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, H3T 1E2, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Mahfouz+R%22">Mahfouz R</searchLink>; Department of Pathology and Laboratory Medicine, American University of Beirut, Beirut, 1107 2020, Lebanon.<br /><searchLink fieldCode="AU" term="%22Minden+MD%22">Minden MD</searchLink>; Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, M5G 2C1, ON, Canada.; Department of Medicine, University of Toronto, Toronto, M5S 1A8, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Jabado+N%22">Jabado N</searchLink>; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.; Department of Pediatrics, McGill University and McGill University Heath Centre Research Institute, Montreal, H4A 3J1, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Bazarbachi+A%22">Bazarbachi A</searchLink>; Department of Internal Medicine, American University of Beirut, Beirut, 1107 2020, Lebanon.; Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, 1107 2020, Lebanon.<br /><searchLink fieldCode="AU" term="%22Eppert+K%22">Eppert K</searchLink>; Department of Pediatrics, McGill University and McGill University Heath Centre Research Institute, Montreal, H4A 3J1, QC, Canada. kolja.eppert@mcgill.ca.
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