Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness.
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| Title: | Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness. |
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| Authors: | Boileau M; Division of Experimental Medicine, McGill University and McGill University Heath Centre Research Institute, Montreal, H4A 3J1, QC, Canada., Shirinian M; Department of Experimental Pathology, Immunology, and Microbiology, American University of Beirut, Beirut, 1107 2020, Lebanon.; Department of Internal Medicine, American University of Beirut, Beirut, 1107 2020, Lebanon., Gayden T; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada., Harutyunyan AS; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada., Chen CCL; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada., Mikael LG; Department of Pediatrics, McGill University and McGill University Heath Centre Research Institute, Montreal, H4A 3J1, QC, Canada., Duncan HM; Division of Experimental Medicine, McGill University and McGill University Heath Centre Research Institute, Montreal, H4A 3J1, QC, Canada., Neumann AL; Research Institute of the McGill University Health Centre and McGill University, Montreal, H4A 3J1, QC, Canada., Arreba-Tutusaus P; Research Institute of the McGill University Health Centre and McGill University, Montreal, H4A 3J1, QC, Canada., De Jay N; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, H3T 1E2, QC, Canada., Zeinieh M; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada., Rossokhata K; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada., Zhang Y; Research Institute of the McGill University Health Centre and McGill University, Montreal, H4A 3J1, QC, Canada., Nikbakht H; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.; McGill University and Génome Québec Innovation Centre, Montreal, H3A 0G1, QC, Canada., Mouawad C; Department of Experimental Pathology, Immunology, and Microbiology, American University of Beirut, Beirut, 1107 2020, Lebanon., Massoud R; Department of Internal Medicine, American University of Beirut, Beirut, 1107 2020, Lebanon., Frey F; Department of Experimental Pathology, Immunology, and Microbiology, American University of Beirut, Beirut, 1107 2020, Lebanon., Nasr R; Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, 1107 2020, Lebanon., El Cheikh J; Department of Internal Medicine, American University of Beirut, Beirut, 1107 2020, Lebanon., El Sabban M; Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, 1107 2020, Lebanon., Kleinman CL; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, H3T 1E2, QC, Canada., Mahfouz R; Department of Pathology and Laboratory Medicine, American University of Beirut, Beirut, 1107 2020, Lebanon., Minden MD; Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, M5G 2C1, ON, Canada.; Department of Medicine, University of Toronto, Toronto, M5S 1A8, ON, Canada., Jabado N; Department of Human Genetics, McGill University, Montreal, H3A 1B1, QC, Canada.; Department of Pediatrics, McGill University and McGill University Heath Centre Research Institute, Montreal, H4A 3J1, QC, Canada., Bazarbachi A; Department of Internal Medicine, American University of Beirut, Beirut, 1107 2020, Lebanon.; Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, 1107 2020, Lebanon., Eppert K; Department of Pediatrics, McGill University and McGill University Heath Centre Research Institute, Montreal, H4A 3J1, QC, Canada. kolja.eppert@mcgill.ca. |
| Source: | Nature communications [Nat Commun] 2019 Jun 28; Vol. 10 (1), pp. 2891. Date of Electronic Publication: 2019 Jun 28. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-019-10705-z |
