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Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment.

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Title: Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment.
Authors: Jackson JJ; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Ketcham JM; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Younai A; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Abraham B; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Biannic B; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Beck HP; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Bui MHT; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Chian D; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Cutler G; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Diokno R; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Hu DX; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Jacobson S; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Karbarz E; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Kassner PD; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Marshall L; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., McKinnell J; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Meleza C; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Okal A; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Pookot D; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Reilly MK; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Robles O; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Shunatona HP; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Talay O; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Walker JR; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Wadsworth A; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Wustrow DJ; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States., Zibinsky M; RAPT Therapeutics , 561 Eccles Avenue , South San Francisco , California 94080 , United States.
Source: Journal of medicinal chemistry [J Med Chem] 2019 Jul 11; Vol. 62 (13), pp. 6190-6213. Date of Electronic Publication: 2019 Jul 01.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of a Potent and Selective CCR4 Antagonist That Inhibits T<subscript>reg</subscript> Trafficking into the Tumor Microenvironment.
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