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MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo.

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Title: MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo.
Authors: Walter K; Department of Internal Medicine I, Ulm University, Germany., Tiwary K; Department of Internal Medicine I, Ulm University, Germany., Trajkovic-Arsic M; Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany.; German Cancer Consortium (DKTK, Partner Site Essen) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Hidalgo-Sastre A; Klinik und Poliklinik für Innere Medizin II, Technical University Munich, Germany., Dierichs L; Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany.; German Cancer Consortium (DKTK, Partner Site Essen) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Liffers ST; Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany.; German Cancer Consortium (DKTK, Partner Site Essen) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Gu J; Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany.; German Cancer Consortium (DKTK, Partner Site Essen) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Gout J; Department of Internal Medicine I, Ulm University, Germany., Schulte LA; Department of Internal Medicine I, Ulm University, Germany., Münch J; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Seufferlein T; Department of Internal Medicine I, Ulm University, Germany., Sainz B Jr; Department of Biochemistry, Universidad Autónoma de Madrid (UAM), Madrid, Spain.; Department of Cancer Biology, Instituto de Investigaciones Biomédicas 'Alberto Sols' (IIBM), CSIC-UAM, Madrid, Spain.; Chronic Diseases and Cancer, Area 3-Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain., Siveke JT; Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany.; German Cancer Consortium (DKTK, Partner Site Essen) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Rodriguez-Aznar E; Department of Internal Medicine I, Ulm University, Germany., Hermann PC; Department of Internal Medicine I, Ulm University, Germany.
Source: Stem cells international [Stem Cells Int] 2019 Jun 02; Vol. 2019, pp. 8475389. Date of Electronic Publication: 2019 Jun 02 (Print Publication: 2019).
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101535822 Publication Model: eCollection Cited Medium: Print ISSN: 1687-966X (Print) NLM ISO Abbreviation: Stem Cells Int Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo.
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  Data: <searchLink fieldCode="AU" term="%22Walter+K%22">Walter K</searchLink>; Department of Internal Medicine I, Ulm University, Germany.<br /><searchLink fieldCode="AU" term="%22Tiwary+K%22">Tiwary K</searchLink>; Department of Internal Medicine I, Ulm University, Germany.<br /><searchLink fieldCode="AU" term="%22Trajkovic-Arsic+M%22">Trajkovic-Arsic M</searchLink>; Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany.; German Cancer Consortium (DKTK, Partner Site Essen) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hidalgo-Sastre+A%22">Hidalgo-Sastre A</searchLink>; Klinik und Poliklinik für Innere Medizin II, Technical University Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Dierichs+L%22">Dierichs L</searchLink>; Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany.; German Cancer Consortium (DKTK, Partner Site Essen) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Liffers+ST%22">Liffers ST</searchLink>; Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany.; German Cancer Consortium (DKTK, Partner Site Essen) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gu+J%22">Gu J</searchLink>; Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany.; German Cancer Consortium (DKTK, Partner Site Essen) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gout+J%22">Gout J</searchLink>; Department of Internal Medicine I, Ulm University, Germany.<br /><searchLink fieldCode="AU" term="%22Schulte+LA%22">Schulte LA</searchLink>; Department of Internal Medicine I, Ulm University, Germany.<br /><searchLink fieldCode="AU" term="%22Münch+J%22">Münch J</searchLink>; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Seufferlein+T%22">Seufferlein T</searchLink>; Department of Internal Medicine I, Ulm University, Germany.<br /><searchLink fieldCode="AU" term="%22Sainz+B+Jr%22">Sainz B Jr</searchLink>; Department of Biochemistry, Universidad Autónoma de Madrid (UAM), Madrid, Spain.; Department of Cancer Biology, Instituto de Investigaciones Biomédicas 'Alberto Sols' (IIBM), CSIC-UAM, Madrid, Spain.; Chronic Diseases and Cancer, Area 3-Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Siveke+JT%22">Siveke JT</searchLink>; Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany.; German Cancer Consortium (DKTK, Partner Site Essen) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Aznar+E%22">Rodriguez-Aznar E</searchLink>; Department of Internal Medicine I, Ulm University, Germany.<br /><searchLink fieldCode="AU" term="%22Hermann+PC%22">Hermann PC</searchLink>; Department of Internal Medicine I, Ulm University, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101535822%22">Stem cells international</searchLink> [Stem Cells Int] 2019 Jun 02; Vol. 2019, pp. 8475389. <i>Date of Electronic Publication: </i>2019 Jun 02 (<i>Print Publication: </i>2019).
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