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Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC.

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Title: Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC.
Authors: Wang KB; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , 575 W Stadium Avenue , West Lafayette , Indiana 47907 , United States., Elsayed MSA; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , 575 W Stadium Avenue , West Lafayette , Indiana 47907 , United States., Wu G; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , 575 W Stadium Avenue , West Lafayette , Indiana 47907 , United States., Deng N; Department of Chemistry and Physical Sciences , Pace University , 1 Pace Plaza , New York , New York 10038 , United States., Cushman M; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , 575 W Stadium Avenue , West Lafayette , Indiana 47907 , United States.; Purdue Center for Cancer Research , 201 S University Street , West Lafayette , Indiana 47906 , United States.; Purdue Institute for Drug Discovery , 720 Clinic Drive , West Lafayette , Indiana 47907 , United States., Yang D; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , 575 W Stadium Avenue , West Lafayette , Indiana 47907 , United States.; Purdue Center for Cancer Research , 201 S University Street , West Lafayette , Indiana 47906 , United States.; Purdue Institute for Drug Discovery , 720 Clinic Drive , West Lafayette , Indiana 47907 , United States.
Source: Journal of the American Chemical Society [J Am Chem Soc] 2019 Jul 17; Vol. 141 (28), pp. 11059-11070. Date of Electronic Publication: 2019 Jul 08.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 31283877
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC.
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  Data: <searchLink fieldCode="AU" term="%22Wang+KB%22">Wang KB</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , 575 W Stadium Avenue , West Lafayette , Indiana 47907 , United States.<br /><searchLink fieldCode="AU" term="%22Elsayed+MSA%22">Elsayed MSA</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , 575 W Stadium Avenue , West Lafayette , Indiana 47907 , United States.<br /><searchLink fieldCode="AU" term="%22Wu+G%22">Wu G</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , 575 W Stadium Avenue , West Lafayette , Indiana 47907 , United States.<br /><searchLink fieldCode="AU" term="%22Deng+N%22">Deng N</searchLink>; Department of Chemistry and Physical Sciences , Pace University , 1 Pace Plaza , New York , New York 10038 , United States.<br /><searchLink fieldCode="AU" term="%22Cushman+M%22">Cushman M</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , 575 W Stadium Avenue , West Lafayette , Indiana 47907 , United States.; Purdue Center for Cancer Research , 201 S University Street , West Lafayette , Indiana 47906 , United States.; Purdue Institute for Drug Discovery , 720 Clinic Drive , West Lafayette , Indiana 47907 , United States.<br /><searchLink fieldCode="AU" term="%22Yang+D%22">Yang D</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy , Purdue University , 575 W Stadium Avenue , West Lafayette , Indiana 47907 , United States.; Purdue Center for Cancer Research , 201 S University Street , West Lafayette , Indiana 47906 , United States.; Purdue Institute for Drug Discovery , 720 Clinic Drive , West Lafayette , Indiana 47907 , United States.
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  Data: <searchLink fieldCode="JN" term="%227503056%22">Journal of the American Chemical Society</searchLink> [J Am Chem Soc] 2019 Jul 17; Vol. 141 (28), pp. 11059-11070. <i>Date of Electronic Publication: </i>2019 Jul 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7503056 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-5126 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200027863%22">00027863 </searchLink><i>NLM ISO Abbreviation: </i>J Am Chem Soc <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1021/jacs.9b02679
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      – Code: eng
        Text: English
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        StartPage: 11059
    Titles:
      – TitleFull: Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC.
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            NameFull: Elsayed MSA
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              Text: 2019 Jul 17
              Type: published
              Y: 2019
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              Value: 141
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              Value: 28
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