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Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan.

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Title: Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan.
Authors: Umotoy J; International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10004, USA., Bagaya BS; UVRI-IAVI HIV Vaccine Program, Entebbe, Uganda; Department of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala-Uganda., Joyce C; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Schiffner T; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) The Scripps Research Institute, La Jolla, CA 92037, USA., Menis S; International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10004, USA., Saye-Francisco KL; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Biddle T; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Mohan S; Department of Medicine, University of California San Diego, San Diego, CA 92103, USA., Vollbrecht T; Department of Medicine, University of California San Diego, San Diego, CA 92103, USA., Kalyuzhniy O; International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10004, USA., Madzorera S; Centre for HIV and STIs, National Institute for Communicable Diseases, of the National Health Laboratory Service (NHLS), Johannesburg 2131, South Africa., Kitchin D; Centre for HIV and STIs, National Institute for Communicable Diseases, of the National Health Laboratory Service (NHLS), Johannesburg 2131, South Africa., Lambson B; Centre for HIV and STIs, National Institute for Communicable Diseases, of the National Health Laboratory Service (NHLS), Johannesburg 2131, South Africa., Nonyane M; Centre for HIV and STIs, National Institute for Communicable Diseases, of the National Health Laboratory Service (NHLS), Johannesburg 2131, South Africa., Kilembe W; Rwanda-Zambia HIV Research Group, Lusaka & Ndola, Zambia., Poignard P; International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA 92037, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Institut de Biologie Structurale, Université Grenoble Alpes, Commissariat a l'Energie Atomique, Centre National de Recherche Scientifique and Centre Hospitalier Universitaire Grenoble Alpes, 38044 Grenoble, France., Schief WR; International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA 92037, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) The Scripps Research Institute, La Jolla, CA 92037, USA., Burton DR; International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA 92037, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02114, USA., Murrell B; Department of Medicine, University of California San Diego, San Diego, CA 92103, USA; Department of Microbiology, Tumor and Cell biology, Karolinska Institutet, Stockholm, Sweden., Moore PL; Centre for HIV and STIs, National Institute for Communicable Diseases, of the National Health Laboratory Service (NHLS), Johannesburg 2131, South Africa; School of Pathology Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of Kwa-Zulu Natal, Durban 4013, South Africa., Briney B; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) The Scripps Research Institute, La Jolla, CA 92037, USA., Sok D; International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10004, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: dsok@iavi.org., Landais E; International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10004, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: elandais@iavi.org.
Corporate Authors: IAVI Protocol C Investigators, IAVI African HIV Research Network
Source: Immunity [Immunity] 2019 Jul 16; Vol. 51 (1), pp. 141-154.e6.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan.
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  Data: <searchLink fieldCode="AU" term="%22Umotoy+J%22">Umotoy J</searchLink>; International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10004, USA.<br /><searchLink fieldCode="AU" term="%22Bagaya+BS%22">Bagaya BS</searchLink>; UVRI-IAVI HIV Vaccine Program, Entebbe, Uganda; Department of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala-Uganda.<br /><searchLink fieldCode="AU" term="%22Joyce+C%22">Joyce C</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Schiffner+T%22">Schiffner T</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Menis+S%22">Menis S</searchLink>; International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10004, USA.<br /><searchLink fieldCode="AU" term="%22Saye-Francisco+KL%22">Saye-Francisco KL</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Biddle+T%22">Biddle T</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Mohan+S%22">Mohan S</searchLink>; Department of Medicine, University of California San Diego, San Diego, CA 92103, USA.<br /><searchLink fieldCode="AU" term="%22Vollbrecht+T%22">Vollbrecht T</searchLink>; Department of Medicine, University of California San Diego, San Diego, CA 92103, USA.<br /><searchLink fieldCode="AU" term="%22Kalyuzhniy+O%22">Kalyuzhniy O</searchLink>; International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10004, USA.<br /><searchLink fieldCode="AU" term="%22Madzorera+S%22">Madzorera S</searchLink>; Centre for HIV and STIs, National Institute for Communicable Diseases, of the National Health Laboratory Service (NHLS), Johannesburg 2131, South Africa.<br /><searchLink fieldCode="AU" term="%22Kitchin+D%22">Kitchin D</searchLink>; Centre for HIV and STIs, National Institute for Communicable Diseases, of the National Health Laboratory Service (NHLS), Johannesburg 2131, South Africa.<br /><searchLink fieldCode="AU" term="%22Lambson+B%22">Lambson B</searchLink>; Centre for HIV and STIs, National Institute for Communicable Diseases, of the National Health Laboratory Service (NHLS), Johannesburg 2131, South Africa.<br /><searchLink fieldCode="AU" term="%22Nonyane+M%22">Nonyane M</searchLink>; Centre for HIV and STIs, National Institute for Communicable Diseases, of the National Health Laboratory Service (NHLS), Johannesburg 2131, South Africa.<br /><searchLink fieldCode="AU" term="%22Kilembe+W%22">Kilembe W</searchLink>; Rwanda-Zambia HIV Research Group, Lusaka & Ndola, Zambia.<br /><searchLink fieldCode="AU" term="%22Poignard+P%22">Poignard P</searchLink>; International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA 92037, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Institut de Biologie Structurale, Université Grenoble Alpes, Commissariat a l'Energie Atomique, Centre National de Recherche Scientifique and Centre Hospitalier Universitaire Grenoble Alpes, 38044 Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Schief+WR%22">Schief WR</searchLink>; International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA 92037, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Burton+DR%22">Burton DR</searchLink>; International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA 92037, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) The Scripps Research Institute, La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Murrell+B%22">Murrell B</searchLink>; Department of Medicine, University of California San Diego, San Diego, CA 92103, USA; Department of Microbiology, Tumor and Cell biology, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Moore+PL%22">Moore PL</searchLink>; Centre for HIV and STIs, National Institute for Communicable Diseases, of the National Health Laboratory Service (NHLS), Johannesburg 2131, South Africa; School of Pathology Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of Kwa-Zulu Natal, Durban 4013, South Africa.<br /><searchLink fieldCode="AU" term="%22Briney+B%22">Briney B</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Sok+D%22">Sok D</searchLink>; International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10004, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: dsok@iavi.org.<br /><searchLink fieldCode="AU" term="%22Landais+E%22">Landais E</searchLink>; International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative, New York, NY 10004, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: elandais@iavi.org.
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