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Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer.

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Title: Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer.
Authors: Raoof S; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA., Mulford IJ; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Frisco-Cabanos H; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA., Nangia V; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA., Timonina D; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA., Labrot E; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Hafeez N; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Bilton SJ; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA., Drier Y; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA., Ji F; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA., Greenberg M; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA., Williams A; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA., Kattermann K; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA., Damon L; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA., Sovath S; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Rakiec DP; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Korn JM; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Ruddy DA; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Benes CH; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hammerman PS; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Piotrowska Z; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Sequist LV; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Niederst MJ; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Barretina J; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Engelman JA; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Hata AN; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA. ahata@mgh.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. ahata@mgh.harvard.edu.
Source: Oncogene [Oncogene] 2019 Sep; Vol. 38 (37), pp. 6399-6413. Date of Electronic Publication: 2019 Jul 19.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
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  Data: Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer.
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  Data: <searchLink fieldCode="AU" term="%22Raoof+S%22">Raoof S</searchLink>; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mulford+IJ%22">Mulford IJ</searchLink>; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Frisco-Cabanos+H%22">Frisco-Cabanos H</searchLink>; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nangia+V%22">Nangia V</searchLink>; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Timonina+D%22">Timonina D</searchLink>; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Labrot+E%22">Labrot E</searchLink>; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hafeez+N%22">Hafeez N</searchLink>; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bilton+SJ%22">Bilton SJ</searchLink>; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Drier+Y%22">Drier Y</searchLink>; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ji+F%22">Ji F</searchLink>; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Greenberg+M%22">Greenberg M</searchLink>; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Williams+A%22">Williams A</searchLink>; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kattermann+K%22">Kattermann K</searchLink>; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Damon+L%22">Damon L</searchLink>; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sovath+S%22">Sovath S</searchLink>; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rakiec+DP%22">Rakiec DP</searchLink>; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Korn+JM%22">Korn JM</searchLink>; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ruddy+DA%22">Ruddy DA</searchLink>; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Benes+CH%22">Benes CH</searchLink>; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hammerman+PS%22">Hammerman PS</searchLink>; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Piotrowska+Z%22">Piotrowska Z</searchLink>; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sequist+LV%22">Sequist LV</searchLink>; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Niederst+MJ%22">Niederst MJ</searchLink>; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Barretina+J%22">Barretina J</searchLink>; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Engelman+JA%22">Engelman JA</searchLink>; Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hata+AN%22">Hata AN</searchLink>; Massachusetts General Hospital (MGH) Cancer Center, Charlestown, MA, USA. ahata@mgh.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. ahata@mgh.harvard.edu.
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