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Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors.

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Title: Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors.
Authors: de Heuvel E; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Singh AK; School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK., Edink E; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., van der Meer T; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., van der Woude M; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Sadek P; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Krell-Jørgensen MP; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., van den Bergh T; Mercachem, Kerkenbos 1013, 6546 BB Nijmegen, The Netherlands., Veerman J; Mercachem, Kerkenbos 1013, 6546 BB Nijmegen, The Netherlands., Caljon G; Laboratory for Microbiology, Parasitology and Hygiene, Universiteitsplein 1, University of Antwerp, 2610 Wilrijk, Belgium., Kalejaiye TD; Institute of Infection, Immunity and Inflammation, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK., Wijtmans M; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Maes L; Laboratory for Microbiology, Parasitology and Hygiene, Universiteitsplein 1, University of Antwerp, 2610 Wilrijk, Belgium., de Koning HP; Institute of Infection, Immunity and Inflammation, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK., Jan Sterk G; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Siderius M; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., de Esch IJP; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Brown DG; School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK., Leurs R; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands. Electronic address: r.leurs@vu.nl.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2019 Sep 15; Vol. 27 (18), pp. 3998-4012. Date of Electronic Publication: 2019 Jun 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22de+Heuvel+E%22">de Heuvel E</searchLink>; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Singh+AK%22">Singh AK</searchLink>; School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.<br /><searchLink fieldCode="AU" term="%22Edink+E%22">Edink E</searchLink>; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Meer+T%22">van der Meer T</searchLink>; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Woude+M%22">van der Woude M</searchLink>; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sadek+P%22">Sadek P</searchLink>; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Krell-Jørgensen+MP%22">Krell-Jørgensen MP</searchLink>; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Bergh+T%22">van den Bergh T</searchLink>; Mercachem, Kerkenbos 1013, 6546 BB Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Veerman+J%22">Veerman J</searchLink>; Mercachem, Kerkenbos 1013, 6546 BB Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Caljon+G%22">Caljon G</searchLink>; Laboratory for Microbiology, Parasitology and Hygiene, Universiteitsplein 1, University of Antwerp, 2610 Wilrijk, Belgium.<br /><searchLink fieldCode="AU" term="%22Kalejaiye+TD%22">Kalejaiye TD</searchLink>; Institute of Infection, Immunity and Inflammation, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK.<br /><searchLink fieldCode="AU" term="%22Wijtmans+M%22">Wijtmans M</searchLink>; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Maes+L%22">Maes L</searchLink>; Laboratory for Microbiology, Parasitology and Hygiene, Universiteitsplein 1, University of Antwerp, 2610 Wilrijk, Belgium.<br /><searchLink fieldCode="AU" term="%22de+Koning+HP%22">de Koning HP</searchLink>; Institute of Infection, Immunity and Inflammation, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK.<br /><searchLink fieldCode="AU" term="%22Jan+Sterk+G%22">Jan Sterk G</searchLink>; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Siderius+M%22">Siderius M</searchLink>; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Esch+IJP%22">de Esch IJP</searchLink>; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Brown+DG%22">Brown DG</searchLink>; School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.<br /><searchLink fieldCode="AU" term="%22Leurs+R%22">Leurs R</searchLink>; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands. Electronic address: r.leurs@vu.nl.
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  Data: <searchLink fieldCode="JN" term="%229413298%22">Bioorganic & medicinal chemistry</searchLink> [Bioorg Med Chem] 2019 Sep 15; Vol. 27 (18), pp. 3998-4012. <i>Date of Electronic Publication: </i>2019 Jun 18.
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