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Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs).

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Title: Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs).
Authors: Reid EE; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States., Archer KE; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States., Shizuka M; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States., McShea MA; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States., Maloney EK; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States., Ab O; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States., Lanieri L; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States., Wilhelm A; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States., Ponte JF; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States., Yoder NC; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States., Chari RVJ; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States., Miller ML; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States. Electronic address: michael.miller@immunogen.com.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Sep 01; Vol. 29 (17), pp. 2455-2458. Date of Electronic Publication: 2019 Jul 19.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs).
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  Data: <searchLink fieldCode="AU" term="%22Reid+EE%22">Reid EE</searchLink>; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States.<br /><searchLink fieldCode="AU" term="%22Archer+KE%22">Archer KE</searchLink>; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States.<br /><searchLink fieldCode="AU" term="%22Shizuka+M%22">Shizuka M</searchLink>; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States.<br /><searchLink fieldCode="AU" term="%22McShea+MA%22">McShea MA</searchLink>; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States.<br /><searchLink fieldCode="AU" term="%22Maloney+EK%22">Maloney EK</searchLink>; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States.<br /><searchLink fieldCode="AU" term="%22Ab+O%22">Ab O</searchLink>; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States.<br /><searchLink fieldCode="AU" term="%22Lanieri+L%22">Lanieri L</searchLink>; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States.<br /><searchLink fieldCode="AU" term="%22Wilhelm+A%22">Wilhelm A</searchLink>; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States.<br /><searchLink fieldCode="AU" term="%22Ponte+JF%22">Ponte JF</searchLink>; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States.<br /><searchLink fieldCode="AU" term="%22Yoder+NC%22">Yoder NC</searchLink>; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States.<br /><searchLink fieldCode="AU" term="%22Chari+RVJ%22">Chari RVJ</searchLink>; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States.<br /><searchLink fieldCode="AU" term="%22Miller+ML%22">Miller ML</searchLink>; ImmunoGen, Inc., 830 Winter Street, Waltham, MA 02451, United States. Electronic address: michael.miller@immunogen.com.
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2019 Sep 01; Vol. 29 (17), pp. 2455-2458. <i>Date of Electronic Publication: </i>2019 Jul 19.
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  Data: Journal Article; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107377 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3405 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220960894X%22">0960894X </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem Lett <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bmcl.2019.07.031
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        Text: English
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              Text: 2019 Sep 01
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