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Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines.

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Title: Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines.
Authors: Fallacara AL; Department of Biotechnology, Chemistry and Pharmacy, 'Department of Excellence 2018-2022', University of Siena, Via Aldo Moro 2, 53100, Siena, Italy., Passannanti R; Department of Biotechnology, Chemistry and Pharmacy, 'Department of Excellence 2018-2022', University of Siena, Via Aldo Moro 2, 53100, Siena, Italy., Mori M; Department of Biotechnology, Chemistry and Pharmacy, 'Department of Excellence 2018-2022', University of Siena, Via Aldo Moro 2, 53100, Siena, Italy., Iovenitti G; Department of Biotechnology, Chemistry and Pharmacy, 'Department of Excellence 2018-2022', University of Siena, Via Aldo Moro 2, 53100, Siena, Italy., Musumeci F; Department of Pharmacy, University of Genoa, Viale Benedetto XV, 3, 16132, Genoa, Italy., Greco C; Department of Pharmacy, University of Genoa, Viale Benedetto XV, 3, 16132, Genoa, Italy., Crespan E; Istituto di Genetica Molecolare, IGM-CNR, Via Abbiategrasso 207, I-27100, Pavia, Italy., Kissova M; Istituto di Genetica Molecolare, IGM-CNR, Via Abbiategrasso 207, I-27100, Pavia, Italy., Maga G; Istituto di Genetica Molecolare, IGM-CNR, Via Abbiategrasso 207, I-27100, Pavia, Italy., Tarantelli C; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), via Vela 6, 6500, Bellinzona, Switzerland., Spriano F; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), via Vela 6, 6500, Bellinzona, Switzerland., Gaudio E; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), via Vela 6, 6500, Bellinzona, Switzerland., Bertoni F; Università della Svizzera italiana (USI), Institute of Oncology Research (IOR), via Vela 6, 6500, Bellinzona, Switzerland., Botta M; Department of Biotechnology, Chemistry and Pharmacy, 'Department of Excellence 2018-2022', University of Siena, Via Aldo Moro 2, 53100, Siena, Italy; Biotechnology College of Science and Technology, Temple University, Biolife Science Building, Suite 333, 1900 N 12th Street, Philadelphia, PA, 19122, United States; Lead Discovery Siena s.r.l., Via Vittorio Alfieri 31, 53019, Castelnuovo, Berardenga, Italy. Electronic address: botta.maurizio@gmail.com., Schenone S; Department of Pharmacy, University of Genoa, Viale Benedetto XV, 3, 16132, Genoa, Italy.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2019 Nov 01; Vol. 181, pp. 111545. Date of Electronic Publication: 2019 Jul 18.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1768-3254
DOI:10.1016/j.ejmech.2019.07.048