Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes.
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| Title: | Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. |
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| Authors: | Wang H; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Lane JM; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Jones SE; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom., Dashti HS; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Ollila HM; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom., van Hees VT; Netherlands eScience Center, Amsterdam, Netherlands., Brumpton B; K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Department of Thoracic and Occupational Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Winsvold BS; K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.; Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway., Kantojärvi K; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland.; Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Palviainen T; Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland., Cade BE; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Sofer T; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Song Y; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Northeastern University College of Science, Boston, MA, USA., Patel K; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Northeastern University College of Science, Boston, MA, USA., Anderson SG; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.; The George Alleyne Chronic Disease Research Centre, Caribbean Institute for Health Research, University of the West Indies, Cave Hill, Barbados., Bechtold DA; Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Bowden J; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Emsley R; Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Kyle SD; Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Little MA; Department of Mathematics, Aston University, Birmingham, UK.; Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA., Loudon AS; Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Scheer FAJL; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Purcell SM; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Richmond RC; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK., Spiegelhalder K; Clinic for Psychiatry and Psychotherapy, Medical Centre, University of Freiburg, Freiburg, Germany., Tyrrell J; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom., Zhu X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Hublin C; Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Kaprio JA; Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Kristiansson K; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland., Sulkava S; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland.; Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Paunio T; Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki, Finland.; Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Hveem K; K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK., Nielsen JB; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Willer CJ; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Zwart JA; Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway., Strand LB; K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom., Ray D; NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX39DU, UK., Lawlor DA; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Rutter MK; Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Manchester Diabetes Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK., Weedon MN; Genetics of Complex Traits, University of Exeter Medical School, Exeter, United Kingdom., Redline S; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Saxena R; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. rsaxena@partners.org.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA. rsaxena@partners.org.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. rsaxena@partners.org.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. rsaxena@partners.org. |
| Source: | Nature communications [Nat Commun] 2019 Aug 13; Vol. 10 (1), pp. 3503. Date of Electronic Publication: 2019 Aug 13. |
| Publication Type: | Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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