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Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits.

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Title: Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits.
Authors: Zhang W; Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA., Voloudakis G; Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Rajagopal VM; Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.; Department of Biomedicine, Aarhus University, 8000, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus University, 8000, Aarhus, Denmark.; Centre for Integrative Sequencing (iSEQ), Aarhus University, 8000, Aarhus, Denmark., Readhead B; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.; The Biodesign Institute, Arizona State University, Tempe, AZ, 85281, USA., Dudley JT; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA., Schadt EE; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA., Björkegren JLM; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.; Clinical Gene Networks AB, 114 44, Stockholm, Sweden.; Vascular Biology Unit, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden.; Department of Physiology, Institute of Biomedicine and Translation Medicine, University of Tartu, 50411, Tartu, Estonia., Kim Y; Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA., Fullard JF; Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA., Hoffman GE; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA., Roussos P; Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. panagiotis.roussos@mssm.edu.; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA. panagiotis.roussos@mssm.edu.; Mental Illness Research Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, Bronx, 10468, NY, USA. panagiotis.roussos@mssm.edu.
Source: Nature communications [Nat Commun] 2019 Aug 23; Vol. 10 (1), pp. 3834. Date of Electronic Publication: 2019 Aug 23.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.<br /><searchLink fieldCode="AU" term="%22Voloudakis+G%22">Voloudakis G</searchLink>; Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.<br /><searchLink fieldCode="AU" term="%22Rajagopal+VM%22">Rajagopal VM</searchLink>; Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.; Department of Biomedicine, Aarhus University, 8000, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus University, 8000, Aarhus, Denmark.; Centre for Integrative Sequencing (iSEQ), Aarhus University, 8000, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Readhead+B%22">Readhead B</searchLink>; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.; The Biodesign Institute, Arizona State University, Tempe, AZ, 85281, USA.<br /><searchLink fieldCode="AU" term="%22Dudley+JT%22">Dudley JT</searchLink>; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.<br /><searchLink fieldCode="AU" term="%22Schadt+EE%22">Schadt EE</searchLink>; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.<br /><searchLink fieldCode="AU" term="%22Björkegren+JLM%22">Björkegren JLM</searchLink>; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.; Clinical Gene Networks AB, 114 44, Stockholm, Sweden.; Vascular Biology Unit, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden.; Department of Physiology, Institute of Biomedicine and Translation Medicine, University of Tartu, 50411, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Kim+Y%22">Kim Y</searchLink>; Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fullard+JF%22">Fullard JF</searchLink>; Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hoffman+GE%22">Hoffman GE</searchLink>; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.<br /><searchLink fieldCode="AU" term="%22Roussos+P%22">Roussos P</searchLink>; Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. panagiotis.roussos@mssm.edu.; Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA. panagiotis.roussos@mssm.edu.; Mental Illness Research Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, Bronx, 10468, NY, USA. panagiotis.roussos@mssm.edu.
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