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Impaired Endothelium-Dependent Hyperpolarization Underlies Endothelial Dysfunction during Early Metabolic Challenge: Increased ROS Generation and Possible Interference with NO Function.

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Title: Impaired Endothelium-Dependent Hyperpolarization Underlies Endothelial Dysfunction during Early Metabolic Challenge: Increased ROS Generation and Possible Interference with NO Function.
Authors: Alaaeddine R; Departments of Pharmacology and Therapeutics (R.A., A.M., A.F.E.-Y.) and Anatomy, Cell Biology, and Physiology (M.E.E.-S.), Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt (M.A.W.E., H.F., E.I.S., A.F.E.-Y.); and Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (F.P.)., Elkhatib MAW; Departments of Pharmacology and Therapeutics (R.A., A.M., A.F.E.-Y.) and Anatomy, Cell Biology, and Physiology (M.E.E.-S.), Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt (M.A.W.E., H.F., E.I.S., A.F.E.-Y.); and Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (F.P.)., Mroueh A; Departments of Pharmacology and Therapeutics (R.A., A.M., A.F.E.-Y.) and Anatomy, Cell Biology, and Physiology (M.E.E.-S.), Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt (M.A.W.E., H.F., E.I.S., A.F.E.-Y.); and Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (F.P.)., Fouad H; Departments of Pharmacology and Therapeutics (R.A., A.M., A.F.E.-Y.) and Anatomy, Cell Biology, and Physiology (M.E.E.-S.), Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt (M.A.W.E., H.F., E.I.S., A.F.E.-Y.); and Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (F.P.)., Saad EI; Departments of Pharmacology and Therapeutics (R.A., A.M., A.F.E.-Y.) and Anatomy, Cell Biology, and Physiology (M.E.E.-S.), Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt (M.A.W.E., H.F., E.I.S., A.F.E.-Y.); and Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (F.P.)., El-Sabban ME; Departments of Pharmacology and Therapeutics (R.A., A.M., A.F.E.-Y.) and Anatomy, Cell Biology, and Physiology (M.E.E.-S.), Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt (M.A.W.E., H.F., E.I.S., A.F.E.-Y.); and Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (F.P.)., Plane F; Departments of Pharmacology and Therapeutics (R.A., A.M., A.F.E.-Y.) and Anatomy, Cell Biology, and Physiology (M.E.E.-S.), Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt (M.A.W.E., H.F., E.I.S., A.F.E.-Y.); and Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (F.P.)., El-Yazbi AF; Departments of Pharmacology and Therapeutics (R.A., A.M., A.F.E.-Y.) and Anatomy, Cell Biology, and Physiology (M.E.E.-S.), Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt (M.A.W.E., H.F., E.I.S., A.F.E.-Y.); and Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (F.P.) ae88@aub.edu.lb.
Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2019 Dec; Vol. 371 (3), pp. 567-582. Date of Electronic Publication: 2019 Sep 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE
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      – TitleFull: Impaired Endothelium-Dependent Hyperpolarization Underlies Endothelial Dysfunction during Early Metabolic Challenge: Increased ROS Generation and Possible Interference with NO Function.
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