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Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56.

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Title: Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56.
Authors: Zou F; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.; Key Laboratory of Tropical Disease Control of Ministry of Education, Guangzhou, Guangdong, 510080, China.; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Guangzhou, Guangdong, 510080, China.; Qianyang Biomedical Research Institute, Guangzhou, Guangdong, 510663, China., Lu L; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.; Key Laboratory of Tropical Disease Control of Ministry of Education, Guangzhou, Guangdong, 510080, China.; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Guangzhou, Guangdong, 510080, China., Liu J; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.; Key Laboratory of Tropical Disease Control of Ministry of Education, Guangzhou, Guangdong, 510080, China.; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Guangzhou, Guangdong, 510080, China., Xia B; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.; Key Laboratory of Tropical Disease Control of Ministry of Education, Guangzhou, Guangdong, 510080, China.; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Guangzhou, Guangdong, 510080, China., Zhang W; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.; Key Laboratory of Tropical Disease Control of Ministry of Education, Guangzhou, Guangdong, 510080, China.; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Guangzhou, Guangdong, 510080, China., Hu Q; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.; Key Laboratory of Tropical Disease Control of Ministry of Education, Guangzhou, Guangdong, 510080, China.; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Guangzhou, Guangdong, 510080, China.; Qianyang Biomedical Research Institute, Guangzhou, Guangdong, 510663, China., Liu W; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.; Key Laboratory of Tropical Disease Control of Ministry of Education, Guangzhou, Guangdong, 510080, China.; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Guangzhou, Guangdong, 510080, China., Zhang Y; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.; Key Laboratory of Tropical Disease Control of Ministry of Education, Guangzhou, Guangdong, 510080, China.; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Guangzhou, Guangdong, 510080, China., Lin Y; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.; Key Laboratory of Tropical Disease Control of Ministry of Education, Guangzhou, Guangdong, 510080, China.; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Guangzhou, Guangdong, 510080, China., Jing S; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.; Key Laboratory of Tropical Disease Control of Ministry of Education, Guangzhou, Guangdong, 510080, China.; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Guangzhou, Guangdong, 510080, China., Huang M; Qianyang Biomedical Research Institute, Guangzhou, Guangdong, 510663, China., Huang B; Qianyang Biomedical Research Institute, Guangzhou, Guangdong, 510663, China., Liu B; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China. liubf5@mail.sysu.edu.cn.; Key Laboratory of Tropical Disease Control of Ministry of Education, Guangzhou, Guangdong, 510080, China. liubf5@mail.sysu.edu.cn.; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Guangzhou, Guangdong, 510080, China. liubf5@mail.sysu.edu.cn., Zhang H; Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China. zhangh92@mail.sysu.edu.cn.; Key Laboratory of Tropical Disease Control of Ministry of Education, Guangzhou, Guangdong, 510080, China. zhangh92@mail.sysu.edu.cn.; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Guangzhou, Guangdong, 510080, China. zhangh92@mail.sysu.edu.cn.; Qianyang Biomedical Research Institute, Guangzhou, Guangdong, 510663, China. zhangh92@mail.sysu.edu.cn.
Source: Nature communications [Nat Commun] 2019 Sep 11; Vol. 10 (1), pp. 4109. Date of Electronic Publication: 2019 Sep 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-019-11893-4