Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models.
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| Title: | Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models. |
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| Authors: | Manzari MT; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Anderson GR; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Lin KH; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Soderquist RS; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Çakir M; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Zhang M; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Moore CE; Department of Neuroscience, Duke University, Durham, NC 27710, USA.; Duke Global Health Institute, Duke University, Durham, NC 27710, USA., Skelton RN; Department of Neuroscience, Duke University, Durham, NC 27710, USA.; Duke Global Health Institute, Duke University, Durham, NC 27710, USA., Fèvre M; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Li X; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Bellucci JJ; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Wardell SE; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Costa SA; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Wood KC; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Chilkoti A; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA. |
| Source: | Science advances [Sci Adv] 2019 Sep 04; Vol. 5 (9), pp. eaaw9162. Date of Electronic Publication: 2019 Sep 04 (Print Publication: 2019). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: eCollection Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 31517048 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Manzari+MT%22">Manzari MT</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+GR%22">Anderson GR</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Lin+KH%22">Lin KH</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Soderquist+RS%22">Soderquist RS</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Çakir+M%22">Çakir M</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Moore+CE%22">Moore CE</searchLink>; Department of Neuroscience, Duke University, Durham, NC 27710, USA.; Duke Global Health Institute, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Skelton+RN%22">Skelton RN</searchLink>; Department of Neuroscience, Duke University, Durham, NC 27710, USA.; Duke Global Health Institute, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Fèvre+M%22">Fèvre M</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Bellucci+JJ%22">Bellucci JJ</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Wardell+SE%22">Wardell SE</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Costa+SA%22">Costa SA</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Wood+KC%22">Wood KC</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Chilkoti+A%22">Chilkoti A</searchLink>; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2019 Sep 04; Vol. 5 (9), pp. eaaw9162. <i>Date of Electronic Publication: </i>2019 Sep 04 (<i>Print Publication: </i>2019). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101653440 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2375-2548 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223752548%22">23752548 </searchLink><i>NLM ISO Abbreviation: </i>Sci Adv <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=31517048 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1126/sciadv.aaw9162 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: eaaw9162 Titles: – TitleFull: Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Manzari MT – PersonEntity: Name: NameFull: Anderson GR – PersonEntity: Name: NameFull: Lin KH – PersonEntity: Name: NameFull: Soderquist RS – PersonEntity: Name: NameFull: Çakir M – PersonEntity: Name: NameFull: Zhang M – PersonEntity: Name: NameFull: Moore CE – PersonEntity: Name: NameFull: Skelton RN – PersonEntity: Name: NameFull: Fèvre M – PersonEntity: Name: NameFull: Li X – PersonEntity: Name: NameFull: Bellucci JJ – PersonEntity: Name: NameFull: Wardell SE – PersonEntity: Name: NameFull: Costa SA – PersonEntity: Name: NameFull: Wood KC – PersonEntity: Name: NameFull: Chilkoti A IsPartOfRelationships: – BibEntity: Dates: – D: 04 M: 09 Text: 2019 Sep 04 Type: published Y: 2019 Identifiers: – Type: issn-electronic Value: 2375-2548 Numbering: – Type: volume Value: 5 – Type: issue Value: 9 Titles: – TitleFull: Science advances Type: main |
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