Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models.
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| Title: | Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models. |
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| Authors: | Manzari MT; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Anderson GR; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Lin KH; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Soderquist RS; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Çakir M; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Zhang M; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Moore CE; Department of Neuroscience, Duke University, Durham, NC 27710, USA.; Duke Global Health Institute, Duke University, Durham, NC 27710, USA., Skelton RN; Department of Neuroscience, Duke University, Durham, NC 27710, USA.; Duke Global Health Institute, Duke University, Durham, NC 27710, USA., Fèvre M; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Li X; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Bellucci JJ; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Wardell SE; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Costa SA; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Wood KC; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Chilkoti A; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA. |
| Source: | Science advances [Sci Adv] 2019 Sep 04; Vol. 5 (9), pp. eaaw9162. Date of Electronic Publication: 2019 Sep 04 (Print Publication: 2019). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: eCollection Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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