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Rapid Identification of Novel Allosteric PRC2 Inhibitors.

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Title: Rapid Identification of Novel Allosteric PRC2 Inhibitors.
Authors: Read JA; Structure and Biophysics, Discovery Sciences , R&D, AstraZeneca , Cambridge , CB4 0WG U.K., Tart J; Discovery Biology, Discovery Sciences , R&D, AstraZeneca , Cambridge , CB4 0WG U.K., Rawlins PB; Structure and Biophysics, Discovery Sciences , R&D, AstraZeneca , Cambridge , CB4 0WG U.K., Gregson C; Medicinal Chemistry , Oncology R&D, AstraZeneca , Cambridge , CB4 0WG U.K., Jones K; Hit Discovery, Discovery Sciences , R&D, AstraZeneca , Macclesfield , SK10 4TG U.K., Gao N; Mechanistic Biology and Profiling, Discovery Sciences , R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States., Zhu X; Mechanistic Biology and Profiling, Discovery Sciences , R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States., Tomlinson R; Discovery Biology, Discovery Sciences , R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States., Code E; Mechanistic Biology and Profiling, Discovery Sciences , R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States., Cheung T; Bioscience, Research and Early Development , Oncology R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States., Chen H; Bioscience, Research and Early Development , Oncology R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States., Kawatkar SP; Medicinal Chemistry , Oncology R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States., Bloecher A; Bioscience, Research and Early Development , Oncology R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States., Bagal S; Medicinal Chemistry , Oncology R&D, AstraZeneca , Cambridge , CB4 0WG U.K., O'Donovan DH; Medicinal Chemistry , Oncology R&D, AstraZeneca , Cambridge , CB4 0WG U.K., Robinson J; Mechanistic Biology and Profiling, Discovery Sciences , R&D, AstraZeneca , Cambridge , CB4 0WG U.K.
Source: ACS chemical biology [ACS Chem Biol] 2019 Oct 18; Vol. 14 (10), pp. 2134-2140. Date of Electronic Publication: 2019 Sep 23.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Read+JA%22">Read JA</searchLink>; Structure and Biophysics, Discovery Sciences , R&D, AstraZeneca , Cambridge , CB4 0WG U.K.<br /><searchLink fieldCode="AU" term="%22Tart+J%22">Tart J</searchLink>; Discovery Biology, Discovery Sciences , R&D, AstraZeneca , Cambridge , CB4 0WG U.K.<br /><searchLink fieldCode="AU" term="%22Rawlins+PB%22">Rawlins PB</searchLink>; Structure and Biophysics, Discovery Sciences , R&D, AstraZeneca , Cambridge , CB4 0WG U.K.<br /><searchLink fieldCode="AU" term="%22Gregson+C%22">Gregson C</searchLink>; Medicinal Chemistry , Oncology R&D, AstraZeneca , Cambridge , CB4 0WG U.K.<br /><searchLink fieldCode="AU" term="%22Jones+K%22">Jones K</searchLink>; Hit Discovery, Discovery Sciences , R&D, AstraZeneca , Macclesfield , SK10 4TG U.K.<br /><searchLink fieldCode="AU" term="%22Gao+N%22">Gao N</searchLink>; Mechanistic Biology and Profiling, Discovery Sciences , R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Zhu+X%22">Zhu X</searchLink>; Mechanistic Biology and Profiling, Discovery Sciences , R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Tomlinson+R%22">Tomlinson R</searchLink>; Discovery Biology, Discovery Sciences , R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Code+E%22">Code E</searchLink>; Mechanistic Biology and Profiling, Discovery Sciences , R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Cheung+T%22">Cheung T</searchLink>; Bioscience, Research and Early Development , Oncology R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Bioscience, Research and Early Development , Oncology R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Kawatkar+SP%22">Kawatkar SP</searchLink>; Medicinal Chemistry , Oncology R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Bloecher+A%22">Bloecher A</searchLink>; Bioscience, Research and Early Development , Oncology R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Bagal+S%22">Bagal S</searchLink>; Medicinal Chemistry , Oncology R&D, AstraZeneca , Cambridge , CB4 0WG U.K.<br /><searchLink fieldCode="AU" term="%22O'Donovan+DH%22">O'Donovan DH</searchLink>; Medicinal Chemistry , Oncology R&D, AstraZeneca , Cambridge , CB4 0WG U.K.<br /><searchLink fieldCode="AU" term="%22Robinson+J%22">Robinson J</searchLink>; Mechanistic Biology and Profiling, Discovery Sciences , R&D, AstraZeneca , Cambridge , CB4 0WG U.K.
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  Data: <searchLink fieldCode="JN" term="%22101282906%22">ACS chemical biology</searchLink> [ACS Chem Biol] 2019 Oct 18; Vol. 14 (10), pp. 2134-2140. <i>Date of Electronic Publication: </i>2019 Sep 23.
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              Text: 2019 Oct 18
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