Rapid Identification of Novel Allosteric PRC2 Inhibitors.
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| Title: | Rapid Identification of Novel Allosteric PRC2 Inhibitors. |
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| Authors: | Read JA; Structure and Biophysics, Discovery Sciences , R&D, AstraZeneca , Cambridge , CB4 0WG U.K., Tart J; Discovery Biology, Discovery Sciences , R&D, AstraZeneca , Cambridge , CB4 0WG U.K., Rawlins PB; Structure and Biophysics, Discovery Sciences , R&D, AstraZeneca , Cambridge , CB4 0WG U.K., Gregson C; Medicinal Chemistry , Oncology R&D, AstraZeneca , Cambridge , CB4 0WG U.K., Jones K; Hit Discovery, Discovery Sciences , R&D, AstraZeneca , Macclesfield , SK10 4TG U.K., Gao N; Mechanistic Biology and Profiling, Discovery Sciences , R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States., Zhu X; Mechanistic Biology and Profiling, Discovery Sciences , R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States., Tomlinson R; Discovery Biology, Discovery Sciences , R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States., Code E; Mechanistic Biology and Profiling, Discovery Sciences , R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States., Cheung T; Bioscience, Research and Early Development , Oncology R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States., Chen H; Bioscience, Research and Early Development , Oncology R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States., Kawatkar SP; Medicinal Chemistry , Oncology R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States., Bloecher A; Bioscience, Research and Early Development , Oncology R&D, AstraZeneca , Waltham , Massachusetts 02451 , United States., Bagal S; Medicinal Chemistry , Oncology R&D, AstraZeneca , Cambridge , CB4 0WG U.K., O'Donovan DH; Medicinal Chemistry , Oncology R&D, AstraZeneca , Cambridge , CB4 0WG U.K., Robinson J; Mechanistic Biology and Profiling, Discovery Sciences , R&D, AstraZeneca , Cambridge , CB4 0WG U.K. |
| Source: | ACS chemical biology [ACS Chem Biol] 2019 Oct 18; Vol. 14 (10), pp. 2134-2140. Date of Electronic Publication: 2019 Sep 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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