Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in Pseudomonas aeruginosa Acute Infection.

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Title: Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in Pseudomonas aeruginosa Acute Infection.
Authors: Khil PP; Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Fredrick, Maryland, USA., Dulanto Chiang A; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Fredrick, Maryland, USA., Ho J; Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA., Youn JH; Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA., Lemon JK; Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA., Gea-Banacloche J; Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, Maryland, USA., Frank KM; Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA., Parta M; Clinical Research Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Fredrick, Maryland, USA., Bonomo RA; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA.; Medical Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.; GRECC, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Case Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Dekker JP; Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA john.dekker@nih.gov.; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Fredrick, Maryland, USA.
Source: MBio [mBio] 2019 Sep 17; Vol. 10 (5). Date of Electronic Publication: 2019 Sep 17.
Publication Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in Pseudomonas aeruginosa Acute Infection.
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  Data: <searchLink fieldCode="AU" term="%22Khil+PP%22">Khil PP</searchLink>; Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Fredrick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Dulanto+Chiang+A%22">Dulanto Chiang A</searchLink>; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Fredrick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Ho+J%22">Ho J</searchLink>; Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Youn+JH%22">Youn JH</searchLink>; Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Lemon+JK%22">Lemon JK</searchLink>; Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Gea-Banacloche+J%22">Gea-Banacloche J</searchLink>; Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Frank+KM%22">Frank KM</searchLink>; Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Parta+M%22">Parta M</searchLink>; Clinical Research Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Fredrick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Bonomo+RA%22">Bonomo RA</searchLink>; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA.; Medical Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.; GRECC, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Case Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Dekker+JP%22">Dekker JP</searchLink>; Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA john.dekker@nih.gov.; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Fredrick, Maryland, USA.
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  Data: <searchLink fieldCode="JN" term="%22101519231%22">MBio</searchLink> [mBio] 2019 Sep 17; Vol. 10 (5). <i>Date of Electronic Publication: </i>2019 Sep 17.
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              Text: 2019 Sep 17
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