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High levels of AAV vector integration into CRISPR-induced DNA breaks.

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Title: High levels of AAV vector integration into CRISPR-induced DNA breaks.
Authors: Hanlon KS; Department of Neurobiology, Harvard Medical School, Boston, MA, 02115, USA.; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, 02129, USA., Kleinstiver BP; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., Garcia SP; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Center for Cancer Research and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA., Zaborowski MP; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Program in Neuroscience, Harvard Medical School, Boston, MA, 02115, USA.; Department of Gynecology, Obstetrics and Gynecologic Oncology, Division of Gynecologic Oncology, Poznań University of Medical Sciences, 60-535, Poznań, Poland., Volak A; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Institute of Molecular and Clinical Ophthalmology Basel, 4031, Basel, Switzerland., Spirig SE; Institute of Molecular and Clinical Ophthalmology Basel, 4031, Basel, Switzerland., Muller A; Institute of Molecular and Clinical Ophthalmology Basel, 4031, Basel, Switzerland., Sousa AA; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Center for Cancer Research and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA., Tsai SQ; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Bengtsson NE; Department of Neurology, University of Washington, Seattle, WA, 98195, USA., Lööv C; Uppsala University, Department of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden., Ingelsson M; Uppsala University, Department of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden., Chamberlain JS; Department of Neurology, University of Washington, Seattle, WA, 98195, USA., Corey DP; Department of Neurobiology, Harvard Medical School, Boston, MA, 02115, USA., Aryee MJ; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Center for Cancer Research and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Joung JK; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Center for Cancer Research and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA., Breakefield XO; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Program in Neuroscience, Harvard Medical School, Boston, MA, 02115, USA., Maguire CA; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, 02129, USA. cmaguire@mgh.harvard.edu.; Program in Neuroscience, Harvard Medical School, Boston, MA, 02115, USA. cmaguire@mgh.harvard.edu., György B; Department of Neurobiology, Harvard Medical School, Boston, MA, 02115, USA. bence.gyoergy@iob.ch.; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, 02129, USA. bence.gyoergy@iob.ch.; Institute of Molecular and Clinical Ophthalmology Basel, 4031, Basel, Switzerland. bence.gyoergy@iob.ch.
Source: Nature communications [Nat Commun] 2019 Sep 30; Vol. 10 (1), pp. 4439. Date of Electronic Publication: 2019 Sep 30.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: High levels of AAV vector integration into CRISPR-induced DNA breaks.
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  Data: <searchLink fieldCode="AU" term="%22Hanlon+KS%22">Hanlon KS</searchLink>; Department of Neurobiology, Harvard Medical School, Boston, MA, 02115, USA.; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, 02129, USA.<br /><searchLink fieldCode="AU" term="%22Kleinstiver+BP%22">Kleinstiver BP</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Garcia+SP%22">Garcia SP</searchLink>; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Center for Cancer Research and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zaborowski+MP%22">Zaborowski MP</searchLink>; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Program in Neuroscience, Harvard Medical School, Boston, MA, 02115, USA.; Department of Gynecology, Obstetrics and Gynecologic Oncology, Division of Gynecologic Oncology, Poznań University of Medical Sciences, 60-535, Poznań, Poland.<br /><searchLink fieldCode="AU" term="%22Volak+A%22">Volak A</searchLink>; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Institute of Molecular and Clinical Ophthalmology Basel, 4031, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Spirig+SE%22">Spirig SE</searchLink>; Institute of Molecular and Clinical Ophthalmology Basel, 4031, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Muller+A%22">Muller A</searchLink>; Institute of Molecular and Clinical Ophthalmology Basel, 4031, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sousa+AA%22">Sousa AA</searchLink>; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Center for Cancer Research and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tsai+SQ%22">Tsai SQ</searchLink>; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Bengtsson+NE%22">Bengtsson NE</searchLink>; Department of Neurology, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Lööv+C%22">Lööv C</searchLink>; Uppsala University, Department of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Ingelsson+M%22">Ingelsson M</searchLink>; Uppsala University, Department of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Chamberlain+JS%22">Chamberlain JS</searchLink>; Department of Neurology, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Corey+DP%22">Corey DP</searchLink>; Department of Neurobiology, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Aryee+MJ%22">Aryee MJ</searchLink>; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Center for Cancer Research and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA.; Department of Biostatistics, Harvard T. 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Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Joung+JK%22">Joung JK</searchLink>; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Center for Cancer Research and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Breakefield+XO%22">Breakefield XO</searchLink>; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, 02129, USA.; Program in Neuroscience, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Maguire+CA%22">Maguire CA</searchLink>; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, 02129, USA. cmaguire@mgh.harvard.edu.; Program in Neuroscience, Harvard Medical School, Boston, MA, 02115, USA. cmaguire@mgh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22György+B%22">György B</searchLink>; Department of Neurobiology, Harvard Medical School, Boston, MA, 02115, USA. bence.gyoergy@iob.ch.; Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, 02129, USA. bence.gyoergy@iob.ch.; Institute of Molecular and Clinical Ophthalmology Basel, 4031, Basel, Switzerland. bence.gyoergy@iob.ch.
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