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Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.

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Title: Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.
Authors: Hughes MM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland., Hooftman A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Angiari S; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Tummala P; John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia., Zaslona Z; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Runtsch MC; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., McGettrick AF; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Sutton CE; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Diskin C; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Rooke M; John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia., Takahashi S; Department of Human Pathology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan., Sundararaj S; John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia., Casarotto MG; John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia., Dahlstrom JE; ACT Pathology and ANU Medical School, The Canberra Hospital, Canberra, ACT, Australia., Palsson-McDermott EM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Corr SC; Department of Microbiology, Moyne Institute of Preventive Medicine, School of Genetics and Microbiology, Trinity College Dublin, Dublin 2, Ireland., Mills KHG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Preston RJS; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland., Neamati N; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, 2800 Plymouth Road, Building 520, Room 1363, Ann Arbor, MI 48109, USA; Translational Oncology Program, University of Michigan, 2800 Plymouth Road, Building 520, Room 1363, Ann Arbor, MI 48109, USA., Xie Y; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Baell JB; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Board PG; John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia., O'Neill LAJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: laoneill@tcd.ie.
Source: Cell reports [Cell Rep] 2019 Oct 01; Vol. 29 (1), pp. 151-161.e5.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.
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  Data: <searchLink fieldCode="AU" term="%22Hughes+MM%22">Hughes MM</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Hooftman+A%22">Hooftman A</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Angiari+S%22">Angiari S</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Tummala+P%22">Tummala P</searchLink>; John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.<br /><searchLink fieldCode="AU" term="%22Zaslona+Z%22">Zaslona Z</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Runtsch+MC%22">Runtsch MC</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22McGettrick+AF%22">McGettrick AF</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Sutton+CE%22">Sutton CE</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Diskin+C%22">Diskin C</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Rooke+M%22">Rooke M</searchLink>; John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.<br /><searchLink fieldCode="AU" term="%22Takahashi+S%22">Takahashi S</searchLink>; Department of Human Pathology, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Sundararaj+S%22">Sundararaj S</searchLink>; John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.<br /><searchLink fieldCode="AU" term="%22Casarotto+MG%22">Casarotto MG</searchLink>; John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.<br /><searchLink fieldCode="AU" term="%22Dahlstrom+JE%22">Dahlstrom JE</searchLink>; ACT Pathology and ANU Medical School, The Canberra Hospital, Canberra, ACT, Australia.<br /><searchLink fieldCode="AU" term="%22Palsson-McDermott+EM%22">Palsson-McDermott EM</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Corr+SC%22">Corr SC</searchLink>; Department of Microbiology, Moyne Institute of Preventive Medicine, School of Genetics and Microbiology, Trinity College Dublin, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Mills+KHG%22">Mills KHG</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Preston+RJS%22">Preston RJS</searchLink>; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.<br /><searchLink fieldCode="AU" term="%22Neamati+N%22">Neamati N</searchLink>; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, 2800 Plymouth Road, Building 520, Room 1363, Ann Arbor, MI 48109, USA; Translational Oncology Program, University of Michigan, 2800 Plymouth Road, Building 520, Room 1363, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Xie+Y%22">Xie Y</searchLink>; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Baell+JB%22">Baell JB</searchLink>; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Board+PG%22">Board PG</searchLink>; John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.<br /><searchLink fieldCode="AU" term="%22O'Neill+LAJ%22">O'Neill LAJ</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: laoneill@tcd.ie.
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