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Pharmacokinetics and short-term safety of the selective NOS inhibitor 2-iminobiotin in asphyxiated neonates treated with therapeutic hypothermia.

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Title: Pharmacokinetics and short-term safety of the selective NOS inhibitor 2-iminobiotin in asphyxiated neonates treated with therapeutic hypothermia.
Authors: Favié LMA; Department of Clinical Pharmacy, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands. l.m.a.favie@umcutrecht.nl.; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands. l.m.a.favie@umcutrecht.nl., Peeters-Scholte CMPCD; Neurophyxia B.V., 's-Hertogenbosch, the Netherlands., Bakker A; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands., Tjabbes H; Neurophyxia B.V., 's-Hertogenbosch, the Netherlands., Egberts TCG; Department of Clinical Pharmacy, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.; Department of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, the Netherlands., van Bel F; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.; UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands., Rademaker CMA; Department of Clinical Pharmacy, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands., Vis P; LAP&P Consultants BV, Leiden, the Netherlands., Groenendaal F; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.; UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.
Source: Pediatric research [Pediatr Res] 2020 Mar; Vol. 87 (4), pp. 689-696. Date of Electronic Publication: 2019 Oct 02.
Publication Type: Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pharmacokinetics and short-term safety of the selective NOS inhibitor 2-iminobiotin in asphyxiated neonates treated with therapeutic hypothermia.
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  Data: <searchLink fieldCode="AU" term="%22Favié+LMA%22">Favié LMA</searchLink>; Department of Clinical Pharmacy, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands. l.m.a.favie@umcutrecht.nl.; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands. l.m.a.favie@umcutrecht.nl.<br /><searchLink fieldCode="AU" term="%22Peeters-Scholte+CMPCD%22">Peeters-Scholte CMPCD</searchLink>; Neurophyxia B.V., 's-Hertogenbosch, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bakker+A%22">Bakker A</searchLink>; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Tjabbes+H%22">Tjabbes H</searchLink>; Neurophyxia B.V., 's-Hertogenbosch, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Egberts+TCG%22">Egberts TCG</searchLink>; Department of Clinical Pharmacy, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.; Department of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Bel+F%22">van Bel F</searchLink>; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.; UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rademaker+CMA%22">Rademaker CMA</searchLink>; Department of Clinical Pharmacy, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Vis+P%22">Vis P</searchLink>; LAP&P Consultants BV, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Groenendaal+F%22">Groenendaal F</searchLink>; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.; UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%220100714%22">Pediatric research</searchLink> [Pediatr Res] 2020 Mar; Vol. 87 (4), pp. 689-696. <i>Date of Electronic Publication: </i>2019 Oct 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0100714 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1530-0447 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200313998%22">00313998 </searchLink><i>NLM ISO Abbreviation: </i>Pediatr Res <i>Subsets: </i>MEDLINE
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              Text: 2020 Mar
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