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DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation.

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Title: DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation.
Authors: Abbotts R; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201., Topper MJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, 21231., Biondi C; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201., Fontaine D; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201., Goswami R; Georgetown College, Georgetown University, Washington, DC 20057., Stojanovic L; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201., Choi EY; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201., McLaughlin L; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201., Kogan AA; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201., Xia L; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, 21231., Lapidus R; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201., Mahmood J; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201., Baylin SB; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, 21231; sbaylin@jhmi.edu frassool@som.umaryland.edu., Rassool FV; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201; sbaylin@jhmi.edu frassool@som.umaryland.edu.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Nov 05; Vol. 116 (45), pp. 22609-22618. Date of Electronic Publication: 2019 Oct 07.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation.
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  Data: <searchLink fieldCode="AU" term="%22Abbotts+R%22">Abbotts R</searchLink>; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201.<br /><searchLink fieldCode="AU" term="%22Topper+MJ%22">Topper MJ</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, 21231.<br /><searchLink fieldCode="AU" term="%22Biondi+C%22">Biondi C</searchLink>; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201.<br /><searchLink fieldCode="AU" term="%22Fontaine+D%22">Fontaine D</searchLink>; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201.<br /><searchLink fieldCode="AU" term="%22Goswami+R%22">Goswami R</searchLink>; Georgetown College, Georgetown University, Washington, DC 20057.<br /><searchLink fieldCode="AU" term="%22Stojanovic+L%22">Stojanovic L</searchLink>; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201.<br /><searchLink fieldCode="AU" term="%22Choi+EY%22">Choi EY</searchLink>; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.<br /><searchLink fieldCode="AU" term="%22McLaughlin+L%22">McLaughlin L</searchLink>; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201.<br /><searchLink fieldCode="AU" term="%22Kogan+AA%22">Kogan AA</searchLink>; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201.<br /><searchLink fieldCode="AU" term="%22Xia+L%22">Xia L</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, 21231.<br /><searchLink fieldCode="AU" term="%22Lapidus+R%22">Lapidus R</searchLink>; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.<br /><searchLink fieldCode="AU" term="%22Mahmood+J%22">Mahmood J</searchLink>; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201.<br /><searchLink fieldCode="AU" term="%22Baylin+SB%22">Baylin SB</searchLink>; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, 21231; sbaylin@jhmi.edu frassool@som.umaryland.edu.<br /><searchLink fieldCode="AU" term="%22Rassool+FV%22">Rassool FV</searchLink>; Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201; sbaylin@jhmi.edu frassool@som.umaryland.edu.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201.
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