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The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer.

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Title: The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer.
Authors: Michaelis KA; Medical Scientist Training Program, Oregon Health & Science University, Portland, OR, USA.; Brenden-Colson Center for Pancreatic Care, Oregon Health & Science University, Portland, OR, USA., Norgard MA; Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR, USA., Zhu X; Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR, USA., Levasseur PR; Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR, USA., Sivagnanam S; Department of Computational Biology, Oregon Health & Science University, Portland, OR, USA., Liudahl SM; Department of Cell, Developmental and Cancer Biology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Burfeind KG; Medical Scientist Training Program, Oregon Health & Science University, Portland, OR, USA., Olson B; Medical Scientist Training Program, Oregon Health & Science University, Portland, OR, USA., Pelz KR; Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR, USA., Angeles Ramos DM; Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR, USA., Maurer HC; Departments of Medicine and Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA., Olive KP; Departments of Medicine and Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA., Coussens LM; Department of Cell, Developmental and Cancer Biology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Morgan TK; Department of Pathology, Oregon Health & Science University, Portland, OR, USA., Marks DL; Brenden-Colson Center for Pancreatic Care, Oregon Health & Science University, Portland, OR, USA. marksd@ohsu.edu.; Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR, USA. marksd@ohsu.edu.
Source: Nature communications [Nat Commun] 2019 Oct 15; Vol. 10 (1), pp. 4682. Date of Electronic Publication: 2019 Oct 15.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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