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4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H3 Receptor Agonists with in Vivo Central Nervous System Activity.

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Title: 4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H3 Receptor Agonists with in Vivo Central Nervous System Activity.
Authors: Wágner G; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands., Mocking TAM; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands., Arimont M; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands., Provensi G, Rani B, Silva-Marques B; Department of Physiotherapy , Federal University of São Carlos , Washington Luís, km 235 , SP-310 São Carlos , Brazil., Latacz G; Department of Technology and Biotechnology of Drugs, Medical College , Jagiellonian University , Medyczna 9 , PL 30-688 Cracow , Poland., Da Costa Pereira D; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands., Karatzidou C; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands., Vischer HF; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands., Wijtmans M; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands., Kieć-Kononowicz K; Department of Technology and Biotechnology of Drugs, Medical College , Jagiellonian University , Medyczna 9 , PL 30-688 Cracow , Poland., de Esch IJP; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands., Leurs R; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands.
Source: Journal of medicinal chemistry [J Med Chem] 2019 Dec 12; Vol. 62 (23), pp. 10848-10866. Date of Electronic Publication: 2019 Nov 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: 4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H<subscript>3</subscript> Receptor Agonists with in Vivo Central Nervous System Activity.
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  Data: <searchLink fieldCode="AU" term="%22Wágner+G%22">Wágner G</searchLink>; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mocking+TAM%22">Mocking TAM</searchLink>; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands.<br /><searchLink fieldCode="AU" term="%22Arimont+M%22">Arimont M</searchLink>; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands.<br /><searchLink fieldCode="AU" term="%22Provensi+G%22">Provensi G</searchLink><br /><searchLink fieldCode="AU" term="%22Rani+B%22">Rani B</searchLink><br /><searchLink fieldCode="AU" term="%22Silva-Marques+B%22">Silva-Marques B</searchLink>; Department of Physiotherapy , Federal University of São Carlos , Washington Luís, km 235 , SP-310 São Carlos , Brazil.<br /><searchLink fieldCode="AU" term="%22Latacz+G%22">Latacz G</searchLink>; Department of Technology and Biotechnology of Drugs, Medical College , Jagiellonian University , Medyczna 9 , PL 30-688 Cracow , Poland.<br /><searchLink fieldCode="AU" term="%22Da+Costa+Pereira+D%22">Da Costa Pereira D</searchLink>; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands.<br /><searchLink fieldCode="AU" term="%22Karatzidou+C%22">Karatzidou C</searchLink>; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vischer+HF%22">Vischer HF</searchLink>; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wijtmans+M%22">Wijtmans M</searchLink>; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kieć-Kononowicz+K%22">Kieć-Kononowicz K</searchLink>; Department of Technology and Biotechnology of Drugs, Medical College , Jagiellonian University , Medyczna 9 , PL 30-688 Cracow , Poland.<br /><searchLink fieldCode="AU" term="%22de+Esch+IJP%22">de Esch IJP</searchLink>; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands.<br /><searchLink fieldCode="AU" term="%22Leurs+R%22">Leurs R</searchLink>; Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Faculty of Science , Vrije Universiteit Amsterdam , De Boelelaan 1108 , 1081 HZ Amsterdam , The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2019 Dec 12; Vol. 62 (23), pp. 10848-10866. <i>Date of Electronic Publication: </i>2019 Nov 20.
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