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Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.

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Title: Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.
Authors: Arboleda-Velasquez JF; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. joseph_arboleda@meei.harvard.edu., Lopera F; Grupo de Neurociencias de Antioquia de la Universidad de Antioquia, Medellin, Colombia., O'Hare M; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Delgado-Tirado S; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Marino C; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Chmielewska N; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.; Boston College, Boston, MA, USA., Saez-Torres KL; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Amarnani D; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Schultz AP; Massachusetts General Hospital and Department of Neurology, Harvard Medical School, Boston, MA, USA., Sperling RA; Massachusetts General Hospital and Department of Neurology, Harvard Medical School, Boston, MA, USA.; Brigham and Women's Hospital and the Department of Neurology, Harvard Medical School, Boston, MA, USA., Leyton-Cifuentes D; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.; Universidad Escuela de Ingenieria de Antioquia-EIA, Medellin, Colombia., Chen K; The Banner Alzheimer's Institute, Phoenix, AZ, USA.; University of Arizona, Tucson, AZ, USA.; Arizona State University, Tempe, AZ, USA., Baena A; Grupo de Neurociencias de Antioquia de la Universidad de Antioquia, Medellin, Colombia., Aguillon D; Grupo de Neurociencias de Antioquia de la Universidad de Antioquia, Medellin, Colombia., Rios-Romenets S; Grupo de Neurociencias de Antioquia de la Universidad de Antioquia, Medellin, Colombia., Giraldo M; Grupo de Neurociencias de Antioquia de la Universidad de Antioquia, Medellin, Colombia., Guzmán-Vélez E; Massachusetts General Hospital and the Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Norton DJ; Massachusetts General Hospital and the Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Department of Psychology, Gordon College, Wenham, MA, USA., Pardilla-Delgado E; Massachusetts General Hospital and the Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Artola A; Massachusetts General Hospital and the Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Sanchez JS; Massachusetts General Hospital and Department of Neurology, Harvard Medical School, Boston, MA, USA., Acosta-Uribe J; Grupo de Neurociencias de Antioquia de la Universidad de Antioquia, Medellin, Colombia.; Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA., Lalli M; Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA., Kosik KS; Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA., Huentelman MJ; Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, AZ, USA., Zetterberg H; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK., Blennow K; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden., Reiman RA; Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, AZ, USA., Luo J; The Banner Alzheimer's Institute, Phoenix, AZ, USA., Chen Y; The Banner Alzheimer's Institute, Phoenix, AZ, USA., Thiyyagura P; The Banner Alzheimer's Institute, Phoenix, AZ, USA., Su Y; The Banner Alzheimer's Institute, Phoenix, AZ, USA., Jun GR; Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Naymik M; Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, AZ, USA., Gai X; Center for Personalized Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.; Department of Pathology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA., Bootwalla M; Center for Personalized Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA., Ji J; Center for Personalized Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.; Department of Pathology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA., Shen L; Center for Personalized Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA., Miller JB; Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Kim LA; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., Tariot PN; The Banner Alzheimer's Institute, Phoenix, AZ, USA.; University of Arizona, Tucson, AZ, USA., Johnson KA; Massachusetts General Hospital and Department of Neurology, Harvard Medical School, Boston, MA, USA.; Brigham and Women's Hospital and the Department of Neurology, Harvard Medical School, Boston, MA, USA.; Massachusetts General Hospital and Department of Radiology, Harvard Medical School, Boston, MA, USA., Reiman EM; The Banner Alzheimer's Institute, Phoenix, AZ, USA. eric.reiman@bannerhealth.com.; University of Arizona, Tucson, AZ, USA. eric.reiman@bannerhealth.com.; Arizona State University, Tempe, AZ, USA. eric.reiman@bannerhealth.com.; Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, AZ, USA. eric.reiman@bannerhealth.com., Quiroz YT; Grupo de Neurociencias de Antioquia de la Universidad de Antioquia, Medellin, Colombia. yquiroz@mgh.harvard.edu.; Massachusetts General Hospital and Department of Neurology, Harvard Medical School, Boston, MA, USA. yquiroz@mgh.harvard.edu.; Massachusetts General Hospital and the Department of Psychiatry, Harvard Medical School, Boston, MA, USA. yquiroz@mgh.harvard.edu.
Source: Nature medicine [Nat Med] 2019 Nov; Vol. 25 (11), pp. 1680-1683. Date of Electronic Publication: 2019 Nov 04.
Publication Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.
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