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New quinoline-2-one/pyrazole derivatives; design, synthesis, molecular docking, anti-apoptotic evaluation, and caspase-3 inhibition assay.

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Title: New quinoline-2-one/pyrazole derivatives; design, synthesis, molecular docking, anti-apoptotic evaluation, and caspase-3 inhibition assay.
Authors: Aly AA; Department of Organic Chemistry, Faculty of Science, Minia University, 61519 ElMinia, Egypt. Electronic address: ashrafaly63@yahoo.com., Sayed SM; Aswan University, Faculty of Science, Chemistry Department, 81529 Aswan, Egypt. Electronic address: aomabdo@yahoo.com., Abdelhafez EMN; Department of Medicinal Chemistry, Faculty of Pharmacy, El-Minia University, 61519, Egypt. Electronic address: shimaanaguib_80@mu.edu.eg., Abdelhafez SMN; Department of Histology, Faculty of Medicine, Minia University, 61519 ElMinia, Egypt. Electronic address: sara_histology@yahoo.com., Abdelzaher WY; Department of Pharmacology, Faculty of Medicine, Minia University, 61519 El-Minia, Egypt. Electronic address: walaayehia22@yahoo.com., Raslan MA; Aswan University, Faculty of Science, Chemistry Department, 81529 Aswan, Egypt. Electronic address: raslanma47@yahoo.com., Ahmed AE; Aswan University, Faculty of Science, Chemistry Department, 81529 Aswan, Egypt. Electronic address: amiraessam394@yahoo.com., Thabet K; Department of Biochemistry, Faculty of Pharmacy, Minia University, 61519 El-Minia, Egypt. Electronic address: khaled_thabet@minia.edu.eg., El-Reedy AAM; Basic and Applied Science Department, Faculty of Oral and Dental Medicine, Nahda University, Beni Suef, Egypt. Electronic address: ahmed.reedy78@gmail.com., Brown AB; Chemistry Program, Florida Institute of Technology, Melbourne, FL 32901, USA. Electronic address: abrown@fit.edu., Bräse S; Institute of Organic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany; Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany. Electronic address: stefan.braese@kit.edu.
Source: Bioorganic chemistry [Bioorg Chem] 2020 Jan; Vol. 94, pp. 103348. Date of Electronic Publication: 2019 Oct 09.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Aly+AA%22">Aly AA</searchLink>; Department of Organic Chemistry, Faculty of Science, Minia University, 61519 ElMinia, Egypt. Electronic address: ashrafaly63@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Sayed+SM%22">Sayed SM</searchLink>; Aswan University, Faculty of Science, Chemistry Department, 81529 Aswan, Egypt. Electronic address: aomabdo@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Abdelhafez+EMN%22">Abdelhafez EMN</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, El-Minia University, 61519, Egypt. Electronic address: shimaanaguib_80@mu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Abdelhafez+SMN%22">Abdelhafez SMN</searchLink>; Department of Histology, Faculty of Medicine, Minia University, 61519 ElMinia, Egypt. Electronic address: sara_histology@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Abdelzaher+WY%22">Abdelzaher WY</searchLink>; Department of Pharmacology, Faculty of Medicine, Minia University, 61519 El-Minia, Egypt. Electronic address: walaayehia22@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Raslan+MA%22">Raslan MA</searchLink>; Aswan University, Faculty of Science, Chemistry Department, 81529 Aswan, Egypt. Electronic address: raslanma47@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Ahmed+AE%22">Ahmed AE</searchLink>; Aswan University, Faculty of Science, Chemistry Department, 81529 Aswan, Egypt. Electronic address: amiraessam394@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Thabet+K%22">Thabet K</searchLink>; Department of Biochemistry, Faculty of Pharmacy, Minia University, 61519 El-Minia, Egypt. Electronic address: khaled_thabet@minia.edu.eg.<br /><searchLink fieldCode="AU" term="%22El-Reedy+AAM%22">El-Reedy AAM</searchLink>; Basic and Applied Science Department, Faculty of Oral and Dental Medicine, Nahda University, Beni Suef, Egypt. Electronic address: ahmed.reedy78@gmail.com.<br /><searchLink fieldCode="AU" term="%22Brown+AB%22">Brown AB</searchLink>; Chemistry Program, Florida Institute of Technology, Melbourne, FL 32901, USA. Electronic address: abrown@fit.edu.<br /><searchLink fieldCode="AU" term="%22Bräse+S%22">Bräse S</searchLink>; Institute of Organic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany; Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany. Electronic address: stefan.braese@kit.edu.
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  Data: <searchLink fieldCode="JN" term="%221303703%22">Bioorganic chemistry</searchLink> [Bioorg Chem] 2020 Jan; Vol. 94, pp. 103348. <i>Date of Electronic Publication: </i>2019 Oct 09.
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