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Novel Benzohydroxamate-Based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis, and Biological Evaluation.

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Title: Novel Benzohydroxamate-Based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis, and Biological Evaluation.
Authors: Vergani B; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Sandrone G; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Marchini M; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Ripamonti C; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Cellupica E; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Galbiati E; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Caprini G; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Pavich G; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Porro G; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Rocchio I; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Lattanzio M; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Pezzuto M; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Skorupska M; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Cordella P; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Pagani P; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Pozzi P; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Pomarico R; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Modena D; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Leoni F; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Perego R; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Fossati G; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Steinkühler C; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy., Stevenazzi A; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.
Source: Journal of medicinal chemistry [J Med Chem] 2019 Dec 12; Vol. 62 (23), pp. 10711-10739. Date of Electronic Publication: 2019 Nov 25.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel Benzohydroxamate-Based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis, and Biological Evaluation.
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  Data: <searchLink fieldCode="AU" term="%22Vergani+B%22">Vergani B</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Sandrone+G%22">Sandrone G</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Marchini+M%22">Marchini M</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Ripamonti+C%22">Ripamonti C</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Cellupica+E%22">Cellupica E</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Galbiati+E%22">Galbiati E</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Caprini+G%22">Caprini G</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Pavich+G%22">Pavich G</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Porro+G%22">Porro G</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Rocchio+I%22">Rocchio I</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Lattanzio+M%22">Lattanzio M</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Pezzuto+M%22">Pezzuto M</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Skorupska+M%22">Skorupska M</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Cordella+P%22">Cordella P</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Pagani+P%22">Pagani P</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Pozzi+P%22">Pozzi P</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Pomarico+R%22">Pomarico R</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Modena+D%22">Modena D</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Leoni+F%22">Leoni F</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Perego+R%22">Perego R</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Fossati+G%22">Fossati G</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Steinkühler+C%22">Steinkühler C</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.<br /><searchLink fieldCode="AU" term="%22Stevenazzi+A%22">Stevenazzi A</searchLink>; Preclinical R&D , Italfarmaco Group , Via dei Lavoratori 54 , I-20092 Cinisello Balsamo , Milan , Italy.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2019 Dec 12; Vol. 62 (23), pp. 10711-10739. <i>Date of Electronic Publication: </i>2019 Nov 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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