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A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension.

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Title: A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension.
Authors: Arnold ND; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Pickworth JA; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., West LE; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Dawson S; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Carvalho JA; Kymab Ltd, Babraham Research Campus, Cambridge, CB22 3AT, UK., Casbolt H; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Braithwaite AT; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Iremonger J; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Renshall L; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Germaschewski V; Kymab Ltd, Babraham Research Campus, Cambridge, CB22 3AT, UK., McCourt M; Kymab Ltd, Babraham Research Campus, Cambridge, CB22 3AT, UK., Bland-Ward P; Kymab Ltd, Babraham Research Campus, Cambridge, CB22 3AT, UK., Kowash H; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Hameed AG; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Rothman AMK; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Frid MG; Cardiovascular Pulmonary Research Laboratories, Departments of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Roger Thompson AA; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Evans HR; Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK., Southwood M; Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's and Papworth Hospital, Cambridge, CB2 0QQ, UK., Morrell NW; Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's and Papworth Hospital, Cambridge, CB2 0QQ, UK., Crossman DC; School of Medicine, University of St. Andrews, St, Andrews, KY16 9AJ, UK., Whyte MKB; MRC/University of Edinburgh Centre for Inflammation Research, University of Edinburgh, The Queens Medical Research Institute, Edinburgh, EH16 4TJ, UK., Stenmark KR; Cardiovascular Pulmonary Research Laboratories, Departments of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Newman CM; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Kiely DG; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.; Sheffield Pulmonary Vascular Disease Unit, Sheffield Teaching Hospitals Foundation Trust, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK., Francis SE; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK., Lawrie A; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK. a.lawrie@sheffield.ac.uk.
Source: Nature communications [Nat Commun] 2019 Nov 15; Vol. 10 (1), pp. 5183. Date of Electronic Publication: 2019 Nov 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension.
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  Data: <searchLink fieldCode="AU" term="%22Arnold+ND%22">Arnold ND</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.<br /><searchLink fieldCode="AU" term="%22Pickworth+JA%22">Pickworth JA</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.<br /><searchLink fieldCode="AU" term="%22West+LE%22">West LE</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.<br /><searchLink fieldCode="AU" term="%22Dawson+S%22">Dawson S</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.<br /><searchLink fieldCode="AU" term="%22Carvalho+JA%22">Carvalho JA</searchLink>; Kymab Ltd, Babraham Research Campus, Cambridge, CB22 3AT, UK.<br /><searchLink fieldCode="AU" term="%22Casbolt+H%22">Casbolt H</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.<br /><searchLink fieldCode="AU" term="%22Braithwaite+AT%22">Braithwaite AT</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.<br /><searchLink fieldCode="AU" term="%22Iremonger+J%22">Iremonger J</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.<br /><searchLink fieldCode="AU" term="%22Renshall+L%22">Renshall L</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.<br /><searchLink fieldCode="AU" term="%22Germaschewski+V%22">Germaschewski V</searchLink>; Kymab Ltd, Babraham Research Campus, Cambridge, CB22 3AT, UK.<br /><searchLink fieldCode="AU" term="%22McCourt+M%22">McCourt M</searchLink>; Kymab Ltd, Babraham Research Campus, Cambridge, CB22 3AT, UK.<br /><searchLink fieldCode="AU" term="%22Bland-Ward+P%22">Bland-Ward P</searchLink>; Kymab Ltd, Babraham Research Campus, Cambridge, CB22 3AT, UK.<br /><searchLink fieldCode="AU" term="%22Kowash+H%22">Kowash H</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.<br /><searchLink fieldCode="AU" term="%22Hameed+AG%22">Hameed AG</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.<br /><searchLink fieldCode="AU" term="%22Rothman+AMK%22">Rothman AMK</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.<br /><searchLink fieldCode="AU" term="%22Frid+MG%22">Frid MG</searchLink>; Cardiovascular Pulmonary Research Laboratories, Departments of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.<br /><searchLink fieldCode="AU" term="%22Roger+Thompson+AA%22">Roger Thompson AA</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.<br /><searchLink fieldCode="AU" term="%22Evans+HR%22">Evans HR</searchLink>; Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK.<br /><searchLink fieldCode="AU" term="%22Southwood+M%22">Southwood M</searchLink>; Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's and Papworth Hospital, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Morrell+NW%22">Morrell NW</searchLink>; Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's and Papworth Hospital, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Crossman+DC%22">Crossman DC</searchLink>; School of Medicine, University of St. Andrews, St, Andrews, KY16 9AJ, UK.<br /><searchLink fieldCode="AU" term="%22Whyte+MKB%22">Whyte MKB</searchLink>; MRC/University of Edinburgh Centre for Inflammation Research, University of Edinburgh, The Queens Medical Research Institute, Edinburgh, EH16 4TJ, UK.<br /><searchLink fieldCode="AU" term="%22Stenmark+KR%22">Stenmark KR</searchLink>; Cardiovascular Pulmonary Research Laboratories, Departments of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.<br /><searchLink fieldCode="AU" term="%22Newman+CM%22">Newman CM</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.<br /><searchLink fieldCode="AU" term="%22Kiely+DG%22">Kiely DG</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.; Sheffield Pulmonary Vascular Disease Unit, Sheffield Teaching Hospitals Foundation Trust, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK.<br /><searchLink fieldCode="AU" term="%22Francis+SE%22">Francis SE</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.<br /><searchLink fieldCode="AU" term="%22Lawrie+A%22">Lawrie A</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK. a.lawrie@sheffield.ac.uk.
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