View in EDS

Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody-Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation.

Saved in:
Bibliographic Details
Title: Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody-Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation.
Authors: Bai C; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Reid EE; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Wilhelm A; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Shizuka M; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Maloney EK; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Laleau R; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Harvey L; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Archer KE; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Vitharana D; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Adams S; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Kovtun Y; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Miller ML; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Chari R; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Keating TA; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States., Yoder NC; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
Source: Bioconjugate chemistry [Bioconjug Chem] 2020 Jan 15; Vol. 31 (1), pp. 93-103. Date of Electronic Publication: 2019 Dec 10.
Publication Type: Comparative Study; Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 31747250
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody-Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Bai+C%22">Bai C</searchLink>; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Reid+EE%22">Reid EE</searchLink>; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Wilhelm+A%22">Wilhelm A</searchLink>; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Shizuka+M%22">Shizuka M</searchLink>; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Maloney+EK%22">Maloney EK</searchLink>; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Laleau+R%22">Laleau R</searchLink>; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Harvey+L%22">Harvey L</searchLink>; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Archer+KE%22">Archer KE</searchLink>; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Vitharana+D%22">Vitharana D</searchLink>; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Adams+S%22">Adams S</searchLink>; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Kovtun+Y%22">Kovtun Y</searchLink>; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Miller+ML%22">Miller ML</searchLink>; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Chari+R%22">Chari R</searchLink>; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Keating+TA%22">Keating TA</searchLink>; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.<br /><searchLink fieldCode="AU" term="%22Yoder+NC%22">Yoder NC</searchLink>; Science, Technology, and Translation , ImmunoGen, Inc. , 830 Winter Street , Waltham , Massachusetts 02451 , United States.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229010319%22">Bioconjugate chemistry</searchLink> [Bioconjug Chem] 2020 Jan 15; Vol. 31 (1), pp. 93-103. <i>Date of Electronic Publication: </i>2019 Dec 10.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Comparative Study; Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9010319 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4812 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210431802%22">10431802 </searchLink><i>NLM ISO Abbreviation: </i>Bioconjug Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=31747250
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.bioconjchem.9b00777
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 93
    Titles:
      – TitleFull: Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody-Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Bai C
      – PersonEntity:
          Name:
            NameFull: Reid EE
      – PersonEntity:
          Name:
            NameFull: Wilhelm A
      – PersonEntity:
          Name:
            NameFull: Shizuka M
      – PersonEntity:
          Name:
            NameFull: Maloney EK
      – PersonEntity:
          Name:
            NameFull: Laleau R
      – PersonEntity:
          Name:
            NameFull: Harvey L
      – PersonEntity:
          Name:
            NameFull: Archer KE
      – PersonEntity:
          Name:
            NameFull: Vitharana D
      – PersonEntity:
          Name:
            NameFull: Adams S
      – PersonEntity:
          Name:
            NameFull: Kovtun Y
      – PersonEntity:
          Name:
            NameFull: Miller ML
      – PersonEntity:
          Name:
            NameFull: Chari R
      – PersonEntity:
          Name:
            NameFull: Keating TA
      – PersonEntity:
          Name:
            NameFull: Yoder NC
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 01
              Text: 2020 Jan 15
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4812
          Numbering:
            – Type: volume
              Value: 31
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Bioconjugate chemistry
              Type: main
ResultId 1