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Strong TH1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy.

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Title: Strong TH1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy.
Authors: Chamcha V; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Reddy PBJ; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Kannanganat S; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Wilkins C; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA., Gangadhara S; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Velu V; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Green R; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA., Law GL; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA., Chang J; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA., Bowen JR; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Kozlowski PA; Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA., Lifton M; Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Santra S; Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Legere T; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Chea LS; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Chennareddi L; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Yu T; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA., Suthar MS; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Silvestri G; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Derdeyn CA; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Gale M Jr; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA., Villinger F; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Hunter E; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA., Amara RR; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. ramara@emory.edu.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.
Source: Science translational medicine [Sci Transl Med] 2019 Nov 20; Vol. 11 (519).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Strong T<subscript>H</subscript>1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy.
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  Data: <searchLink fieldCode="AU" term="%22Chamcha+V%22">Chamcha V</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Reddy+PBJ%22">Reddy PBJ</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Kannanganat+S%22">Kannanganat S</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Wilkins+C%22">Wilkins C</searchLink>; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA.<br /><searchLink fieldCode="AU" term="%22Gangadhara+S%22">Gangadhara S</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Velu+V%22">Velu V</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Green+R%22">Green R</searchLink>; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA.<br /><searchLink fieldCode="AU" term="%22Law+GL%22">Law GL</searchLink>; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA.<br /><searchLink fieldCode="AU" term="%22Chang+J%22">Chang J</searchLink>; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA.<br /><searchLink fieldCode="AU" term="%22Bowen+JR%22">Bowen JR</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Kozlowski+PA%22">Kozlowski PA</searchLink>; Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.<br /><searchLink fieldCode="AU" term="%22Lifton+M%22">Lifton M</searchLink>; Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Santra+S%22">Santra S</searchLink>; Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Legere+T%22">Legere T</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Chea+LS%22">Chea LS</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Chennareddi+L%22">Chennareddi L</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Yu+T%22">Yu T</searchLink>; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Suthar+MS%22">Suthar MS</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Silvestri+G%22">Silvestri G</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Derdeyn+CA%22">Derdeyn CA</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Gale+M+Jr%22">Gale M Jr</searchLink>; Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, Seattle, WA 981909, USA.<br /><searchLink fieldCode="AU" term="%22Villinger+F%22">Villinger F</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Hunter+E%22">Hunter E</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Amara+RR%22">Amara RR</searchLink>; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. ramara@emory.edu.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.
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