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Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression.

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Title: Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression.
Authors: Ferreira RC; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Castro Dopico X; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., Oliveira JJ; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., Rainbow DB; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Yang JH; Department of Immunobiology, NIHR Biomedical Research Centre, King's College London, London, United Kingdom., Trzupek D; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Todd SA; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., McNeill M; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., Steri M; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy., Orrù V; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy., Fiorillo E; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy., Crouch DJM; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Pekalski ML; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Cucca F; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy.; Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy., Tree TI; Department of Immunobiology, NIHR Biomedical Research Centre, King's College London, London, United Kingdom., Vyse TJ; Department of Medical & Molecular Genetics, King's College London, Guy's Hospital, London, United Kingdom., Wicker LS; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Todd JA; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.
Source: Frontiers in immunology [Front Immunol] 2019 Nov 08; Vol. 10, pp. 2606. Date of Electronic Publication: 2019 Nov 08 (Print Publication: 2019).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp<superscript>620</superscript> Risk Allele Drive the Expansion of FOXP3<superscript>+</superscript> Regulatory T Cells and PD-1 Expression.
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  Data: <searchLink fieldCode="AU" term="%22Ferreira+RC%22">Ferreira RC</searchLink>; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Castro+Dopico+X%22">Castro Dopico X</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Oliveira+JJ%22">Oliveira JJ</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Rainbow+DB%22">Rainbow DB</searchLink>; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Yang+JH%22">Yang JH</searchLink>; Department of Immunobiology, NIHR Biomedical Research Centre, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Trzupek+D%22">Trzupek D</searchLink>; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Todd+SA%22">Todd SA</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22McNeill+M%22">McNeill M</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Steri+M%22">Steri M</searchLink>; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Orrù+V%22">Orrù V</searchLink>; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Fiorillo+E%22">Fiorillo E</searchLink>; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Crouch+DJM%22">Crouch DJM</searchLink>; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pekalski+ML%22">Pekalski ML</searchLink>; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cucca+F%22">Cucca F</searchLink>; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy.; Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy.<br /><searchLink fieldCode="AU" term="%22Tree+TI%22">Tree TI</searchLink>; Department of Immunobiology, NIHR Biomedical Research Centre, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Vyse+TJ%22">Vyse TJ</searchLink>; Department of Medical & Molecular Genetics, King's College London, Guy's Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wicker+LS%22">Wicker LS</searchLink>; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Todd+JA%22">Todd JA</searchLink>; JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2019 Nov 08; Vol. 10, pp. 2606. <i>Date of Electronic Publication: </i>2019 Nov 08 (<i>Print Publication: </i>2019).
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