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Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.

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Title: Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.
Authors: Casci I; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Krishnamurthy K; Department of Neuroscience, Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Jefferson University, Philadelphia, PA, USA., Kour S; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Tripathy V; Center for Regenerative Therapies TU Dresden, Technische Universität Dresden, Fetscherstr. 105, 01307, Dresden, Germany., Ramesh N; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Anderson EN; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Marrone L; Center for Regenerative Therapies TU Dresden, Technische Universität Dresden, Fetscherstr. 105, 01307, Dresden, Germany., Grant RA; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Oliver S; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Gochenaur L; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Patel K; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Sterneckert J; Center for Regenerative Therapies TU Dresden, Technische Universität Dresden, Fetscherstr. 105, 01307, Dresden, Germany., Gleixner AM; Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Live Like Lou Center for ALS Research, Brain Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Donnelly CJ; Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Live Like Lou Center for ALS Research, Brain Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Ruepp MD; UK Dementia Research Institute at King's College London, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, SE5 9NU, UK., Sini AM; Department of Biomedical Sciences (DBS), University of Padova, Padova, Italy., Zuccaro E; Department of Biomedical Sciences (DBS), University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy., Pennuto M; Department of Biomedical Sciences (DBS), University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy., Pasinelli P; Department of Neuroscience, Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Jefferson University, Philadelphia, PA, USA., Pandey UB; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA. udai@pitt.edu.; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. udai@pitt.edu.
Source: Nature communications [Nat Commun] 2019 Dec 06; Vol. 10 (1), pp. 5583. Date of Electronic Publication: 2019 Dec 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.
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  Data: <searchLink fieldCode="AU" term="%22Casci+I%22">Casci I</searchLink>; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Krishnamurthy+K%22">Krishnamurthy K</searchLink>; Department of Neuroscience, Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Jefferson University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kour+S%22">Kour S</searchLink>; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tripathy+V%22">Tripathy V</searchLink>; Center for Regenerative Therapies TU Dresden, Technische Universität Dresden, Fetscherstr. 105, 01307, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Ramesh+N%22">Ramesh N</searchLink>; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+EN%22">Anderson EN</searchLink>; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Marrone+L%22">Marrone L</searchLink>; Center for Regenerative Therapies TU Dresden, Technische Universität Dresden, Fetscherstr. 105, 01307, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Grant+RA%22">Grant RA</searchLink>; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Oliver+S%22">Oliver S</searchLink>; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gochenaur+L%22">Gochenaur L</searchLink>; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Patel+K%22">Patel K</searchLink>; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sterneckert+J%22">Sterneckert J</searchLink>; Center for Regenerative Therapies TU Dresden, Technische Universität Dresden, Fetscherstr. 105, 01307, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Gleixner+AM%22">Gleixner AM</searchLink>; Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Live Like Lou Center for ALS Research, Brain Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Donnelly+CJ%22">Donnelly CJ</searchLink>; Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Live Like Lou Center for ALS Research, Brain Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ruepp+MD%22">Ruepp MD</searchLink>; UK Dementia Research Institute at King's College London, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, SE5 9NU, UK.<br /><searchLink fieldCode="AU" term="%22Sini+AM%22">Sini AM</searchLink>; Department of Biomedical Sciences (DBS), University of Padova, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Zuccaro+E%22">Zuccaro E</searchLink>; Department of Biomedical Sciences (DBS), University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Pennuto+M%22">Pennuto M</searchLink>; Department of Biomedical Sciences (DBS), University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine (VIMM), Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Pasinelli+P%22">Pasinelli P</searchLink>; Department of Neuroscience, Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Jefferson University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Pandey+UB%22">Pandey UB</searchLink>; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA. udai@pitt.edu.; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. udai@pitt.edu.
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