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In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells.

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Title: In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells.
Authors: Montoya JJ; The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA. justinjmontoya@email.arizona.edu.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA. justinjmontoya@email.arizona.edu., Turnidge MA; The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA.; School of Life Sciences, Arizona State University, Tempe, AZ, USA.; Present Address: Department of Molecular & Medical Genetics, Oregon Health and Science University, Portland, OR, 97239, USA., Wai DH; The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA., Patel AR; The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ, USA., Lee DW; The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA., Gokhale V; University of Arizona College of Pharmacy, Tucson, AZ, USA., Hurley LH; University of Arizona College of Pharmacy, Tucson, AZ, USA., Arceci RJ; The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ, USA., Wetmore C; The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ, USA., Azorsa DO; The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Present Address: Systems Oncology, Scottsdale, AZ, 85255, USA.
Source: BMC cancer [BMC Cancer] 2019 Dec 27; Vol. 19 (1), pp. 1251. Date of Electronic Publication: 2019 Dec 27.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells.
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  Data: <searchLink fieldCode="AU" term="%22Montoya+JJ%22">Montoya JJ</searchLink>; The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA. justinjmontoya@email.arizona.edu.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA. justinjmontoya@email.arizona.edu.<br /><searchLink fieldCode="AU" term="%22Turnidge+MA%22">Turnidge MA</searchLink>; The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA.; School of Life Sciences, Arizona State University, Tempe, AZ, USA.; Present Address: Department of Molecular & Medical Genetics, Oregon Health and Science University, Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Wai+DH%22">Wai DH</searchLink>; The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA.<br /><searchLink fieldCode="AU" term="%22Patel+AR%22">Patel AR</searchLink>; The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Lee+DW%22">Lee DW</searchLink>; The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA.<br /><searchLink fieldCode="AU" term="%22Gokhale+V%22">Gokhale V</searchLink>; University of Arizona College of Pharmacy, Tucson, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Hurley+LH%22">Hurley LH</searchLink>; University of Arizona College of Pharmacy, Tucson, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Arceci+RJ%22">Arceci RJ</searchLink>; The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Wetmore+C%22">Wetmore C</searchLink>; The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Azorsa+DO%22">Azorsa DO</searchLink>; The Institute of Molecular Medicine at Phoenix Children's Hospital, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Department of Child Health, The University of Arizona College of Medicine-Phoenix, 475 N 5th Street, Phoenix, AZ, 85004, USA.; Present Address: Systems Oncology, Scottsdale, AZ, 85255, USA.
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  Data: <searchLink fieldCode="JN" term="%22100967800%22">BMC cancer</searchLink> [BMC Cancer] 2019 Dec 27; Vol. 19 (1), pp. 1251. <i>Date of Electronic Publication: </i>2019 Dec 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100967800 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1471-2407 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214712407%22">14712407 </searchLink><i>NLM ISO Abbreviation: </i>BMC Cancer <i>Subsets: </i>MEDLINE
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              Text: 2019 Dec 27
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