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Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity.

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Title: Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity.
Authors: Melms JC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Columbia University Medical Center, Division of Hematology and Oncology, New York, New York.; Columbia Center for Translational Immunology, New York, New York., Vallabhaneni S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts., Mills CE; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts., Yapp C; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts., Chen JY; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts., Morelli E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Waszyk P; Experimental Pathology Service, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland., Kumar S; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Immunology, Harvard Medical School, Boston, Massachusetts., Deming D; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts., Moret N; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts., Rodriguez S; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts., Subramanian K; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts., Rogava M; Columbia University Medical Center, Division of Hematology and Oncology, New York, New York.; Columbia Center for Translational Immunology, New York, New York.; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts., Cartwright ANR; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts., Luoma A; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts., Mei S; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts., Brinker TJ; National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany., Miller DM; Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts., Spektor A; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Schadendorf D; Department of Dermatology, University Hospital Essen and German Cancer Consortium (DKTK), Essen, Germany., Riggi N; Experimental Pathology Service, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland., Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Immunology, Harvard Medical School, Boston, Massachusetts., Sorger PK; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.; Ludwig Center for Cancer Research at Harvard, Boston, Massachusetts., Izar B; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Bi2175@cumc.columbia.edu.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Columbia University Medical Center, Division of Hematology and Oncology, New York, New York.; Columbia Center for Translational Immunology, New York, New York.; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.; Ludwig Center for Cancer Research at Harvard, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Source: Cancer research [Cancer Res] 2020 Feb 15; Vol. 80 (4), pp. 798-810. Date of Electronic Publication: 2019 Dec 27.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
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  Data: Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity.
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  Data: <searchLink fieldCode="AU" term="%22Melms+JC%22">Melms JC</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Columbia University Medical Center, Division of Hematology and Oncology, New York, New York.; Columbia Center for Translational Immunology, New York, New York.<br /><searchLink fieldCode="AU" term="%22Vallabhaneni+S%22">Vallabhaneni S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Mills+CE%22">Mills CE</searchLink>; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Yapp+C%22">Yapp C</searchLink>; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Chen+JY%22">Chen JY</searchLink>; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Morelli+E%22">Morelli E</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Waszyk+P%22">Waszyk P</searchLink>; Experimental Pathology Service, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kumar+S%22">Kumar S</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Immunology, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Deming+D%22">Deming D</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Moret+N%22">Moret N</searchLink>; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Rodriguez+S%22">Rodriguez S</searchLink>; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Subramanian+K%22">Subramanian K</searchLink>; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Rogava+M%22">Rogava M</searchLink>; Columbia University Medical Center, Division of Hematology and Oncology, New York, New York.; Columbia Center for Translational Immunology, New York, New York.; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Cartwright+ANR%22">Cartwright ANR</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Luoma+A%22">Luoma A</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Mei+S%22">Mei S</searchLink>; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Brinker+TJ%22">Brinker TJ</searchLink>; National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Miller+DM%22">Miller DM</searchLink>; Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Spektor+A%22">Spektor A</searchLink>; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Schadendorf+D%22">Schadendorf D</searchLink>; Department of Dermatology, University Hospital Essen and German Cancer Consortium (DKTK), Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Riggi+N%22">Riggi N</searchLink>; Experimental Pathology Service, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wucherpfennig+KW%22">Wucherpfennig KW</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Immunology, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Sorger+PK%22">Sorger PK</searchLink>; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.; Ludwig Center for Cancer Research at Harvard, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Izar+B%22">Izar B</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Bi2175@cumc.columbia.edu.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Columbia University Medical Center, Division of Hematology and Oncology, New York, New York.; Columbia Center for Translational Immunology, New York, New York.; Laboratory for Systems Pharmacology, Harvard Medical School, Boston, Massachusetts.; Ludwig Center for Cancer Research at Harvard, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
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  Data: <searchLink fieldCode="JN" term="%222984705R%22">Cancer research</searchLink> [Cancer Res] 2020 Feb 15; Vol. 80 (4), pp. 798-810. <i>Date of Electronic Publication: </i>2019 Dec 27.
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