Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site.
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| Title: | Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site. |
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| Authors: | Chaton CT; Department of Molecular & Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, KY, 40536, USA., Rodriguez ES; Department of Molecular & Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, KY, 40536, USA.; Department of Chemistry & Biochemistry, Ohio State University, Columbus, OH, 43210, USA., Reed RW; Department of Molecular & Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, KY, 40536, USA.; Division of Regulatory Services, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, 40546, USA., Li J; Department of Molecular & Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, KY, 40536, USA.; Gannan Medical University, Ganzhou, Jiangxi, 341000, China., Kenner CW; Department of Molecular & Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, KY, 40536, USA.; Georgetown College, Georgetown, KY, 40324, USA., Korotkov KV; Department of Molecular & Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, KY, 40536, USA. kkorotkov@uky.edu. |
| Source: | Scientific reports [Sci Rep] 2019 Dec 30; Vol. 9 (1), pp. 20267. Date of Electronic Publication: 2019 Dec 30. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 31889085 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Chaton+CT%22">Chaton CT</searchLink>; Department of Molecular & Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, KY, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+ES%22">Rodriguez ES</searchLink>; Department of Molecular & Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, KY, 40536, USA.; Department of Chemistry & Biochemistry, Ohio State University, Columbus, OH, 43210, USA.<br /><searchLink fieldCode="AU" term="%22Reed+RW%22">Reed RW</searchLink>; Department of Molecular & Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, KY, 40536, USA.; Division of Regulatory Services, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, 40546, USA.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Molecular & Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, KY, 40536, USA.; Gannan Medical University, Ganzhou, Jiangxi, 341000, China.<br /><searchLink fieldCode="AU" term="%22Kenner+CW%22">Kenner CW</searchLink>; Department of Molecular & Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, KY, 40536, USA.; Georgetown College, Georgetown, KY, 40324, USA.<br /><searchLink fieldCode="AU" term="%22Korotkov+KV%22">Korotkov KV</searchLink>; Department of Molecular & Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, KY, 40536, USA. kkorotkov@uky.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2019 Dec 30; Vol. 9 (1), pp. 20267. <i>Date of Electronic Publication: </i>2019 Dec 30. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101563288 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2045-2322 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220452322%22">20452322 </searchLink><i>NLM ISO Abbreviation: </i>Sci Rep <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=31889085 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41598-019-56722-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 20267 Titles: – TitleFull: Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chaton CT – PersonEntity: Name: NameFull: Rodriguez ES – PersonEntity: Name: NameFull: Reed RW – PersonEntity: Name: NameFull: Li J – PersonEntity: Name: NameFull: Kenner CW – PersonEntity: Name: NameFull: Korotkov KV IsPartOfRelationships: – BibEntity: Dates: – D: 30 M: 12 Text: 2019 Dec 30 Type: published Y: 2019 Identifiers: – Type: issn-electronic Value: 2045-2322 Numbering: – Type: volume Value: 9 – Type: issue Value: 1 Titles: – TitleFull: Scientific reports Type: main |
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