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Genome-Wide Polygenic Score and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease: A Nested Case-Control Study.

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Title: Genome-Wide Polygenic Score and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease: A Nested Case-Control Study.
Authors: Emdin CA; Center for Genomic Medicine, Massachusetts General Hospital, Boston (C.A.E., A.V.K.).; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard (C.A.E., M.W., A.V.K.)., Bhatnagar P; Eli Lilly and Co, Indianapolis, IN (P.B., S.G.P., H.-R.Q., J.S.R., G.R.)., Wang M; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard (C.A.E., M.W., A.V.K.)., Pillai SG; Eli Lilly and Co, Indianapolis, IN (P.B., S.G.P., H.-R.Q., J.S.R., G.R.)., Li L; BioStat Solutions, Inc, Frederick, MD (L.L.)., Qian HR; Eli Lilly and Co, Indianapolis, IN (P.B., S.G.P., H.-R.Q., J.S.R., G.R.)., Riesmeyer JS; Eli Lilly and Co, Indianapolis, IN (P.B., S.G.P., H.-R.Q., J.S.R., G.R.)., Lincoff AM; The Cleveland Clinic Coordinating Center for Clinical Research, Department of Cardiovascular Medicine, Cleveland Clinic, OH (A.M.L., S.E.N.)., Nicholls SJ; Monash Cardiovascular Research Centre, Monash University, Clayton VIC, Australia (S.J.N.)., Nissen SE; The Cleveland Clinic Coordinating Center for Clinical Research, Department of Cardiovascular Medicine, Cleveland Clinic, OH (A.M.L., S.E.N.)., Ruotolo G; Eli Lilly and Co, Indianapolis, IN (P.B., S.G.P., H.-R.Q., J.S.R., G.R.)., Kathiresan S; Verve Therapeutics, Cambridge, MA (S.K.)., Khera AV; Center for Genomic Medicine, Massachusetts General Hospital, Boston (C.A.E., A.V.K.).; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard (C.A.E., M.W., A.V.K.).
Source: Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2020 Feb; Vol. 13 (1), pp. e002767. Date of Electronic Publication: 2020 Jan 03.
Publication Type: Letter; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101714113 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2574-8300 (Electronic) Linking ISSN: 25748300 NLM ISO Abbreviation: Circ Genom Precis Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genome-Wide Polygenic Score and Cardiovascular Outcomes With Evacetrapib in Patients With High-Risk Vascular Disease: A Nested Case-Control Study.
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  Data: <searchLink fieldCode="AU" term="%22Emdin+CA%22">Emdin CA</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston (C.A.E., A.V.K.).; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard (C.A.E., M.W., A.V.K.).<br /><searchLink fieldCode="AU" term="%22Bhatnagar+P%22">Bhatnagar P</searchLink>; Eli Lilly and Co, Indianapolis, IN (P.B., S.G.P., H.-R.Q., J.S.R., G.R.).<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard (C.A.E., M.W., A.V.K.).<br /><searchLink fieldCode="AU" term="%22Pillai+SG%22">Pillai SG</searchLink>; Eli Lilly and Co, Indianapolis, IN (P.B., S.G.P., H.-R.Q., J.S.R., G.R.).<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; BioStat Solutions, Inc, Frederick, MD (L.L.).<br /><searchLink fieldCode="AU" term="%22Qian+HR%22">Qian HR</searchLink>; Eli Lilly and Co, Indianapolis, IN (P.B., S.G.P., H.-R.Q., J.S.R., G.R.).<br /><searchLink fieldCode="AU" term="%22Riesmeyer+JS%22">Riesmeyer JS</searchLink>; Eli Lilly and Co, Indianapolis, IN (P.B., S.G.P., H.-R.Q., J.S.R., G.R.).<br /><searchLink fieldCode="AU" term="%22Lincoff+AM%22">Lincoff AM</searchLink>; The Cleveland Clinic Coordinating Center for Clinical Research, Department of Cardiovascular Medicine, Cleveland Clinic, OH (A.M.L., S.E.N.).<br /><searchLink fieldCode="AU" term="%22Nicholls+SJ%22">Nicholls SJ</searchLink>; Monash Cardiovascular Research Centre, Monash University, Clayton VIC, Australia (S.J.N.).<br /><searchLink fieldCode="AU" term="%22Nissen+SE%22">Nissen SE</searchLink>; The Cleveland Clinic Coordinating Center for Clinical Research, Department of Cardiovascular Medicine, Cleveland Clinic, OH (A.M.L., S.E.N.).<br /><searchLink fieldCode="AU" term="%22Ruotolo+G%22">Ruotolo G</searchLink>; Eli Lilly and Co, Indianapolis, IN (P.B., S.G.P., H.-R.Q., J.S.R., G.R.).<br /><searchLink fieldCode="AU" term="%22Kathiresan+S%22">Kathiresan S</searchLink>; Verve Therapeutics, Cambridge, MA (S.K.).<br /><searchLink fieldCode="AU" term="%22Khera+AV%22">Khera AV</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston (C.A.E., A.V.K.).; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard (C.A.E., M.W., A.V.K.).
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              Text: 2020 Feb
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