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The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.

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Title: The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.
Authors: Kitchen GB; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.; Manchester Foundation Trust, Manchester Academic Health Science Centre, M13 9WL Manchester, United Kingdom., Cunningham PS; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom., Poolman TM; National Institute for Health Research, John Radcliffe Hospital, Oxford Biomedical Research Centre, OX3 9DU Oxford, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX37LE Oxford, United Kingdom., Iqbal M; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom., Maidstone R; National Institute for Health Research, John Radcliffe Hospital, Oxford Biomedical Research Centre, OX3 9DU Oxford, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX37LE Oxford, United Kingdom., Baxter M; National Institute for Health Research, John Radcliffe Hospital, Oxford Biomedical Research Centre, OX3 9DU Oxford, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX37LE Oxford, United Kingdom., Bagnall J; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom., Begley N; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom., Saer B; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom., Hussell T; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom., Matthews LC; Leeds Institute of Cancer and Pathology, Faculty of Medicine and Health, University of Leeds, LS9 7TF Leeds, United Kingdom., Dockrell DH; Department of Infection Medicine and Medical Research Council Centre for Inflammation Research, University of Edinburgh, EH16 4TJ Edinburgh, United Kingdom., Durrington HJ; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.; Manchester Foundation Trust, Manchester Academic Health Science Centre, M13 9WL Manchester, United Kingdom., Gibbs JE; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom., Blaikley JF; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom; john.blaikley@manchester.ac.uk andrew.loudon@manchester.ac.uk David.Ray@ocdem.ox.ac.uk.; Manchester Foundation Trust, Manchester Academic Health Science Centre, M13 9WL Manchester, United Kingdom., Loudon AS; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom; john.blaikley@manchester.ac.uk andrew.loudon@manchester.ac.uk David.Ray@ocdem.ox.ac.uk., Ray DW; National Institute for Health Research, John Radcliffe Hospital, Oxford Biomedical Research Centre, OX3 9DU Oxford, United Kingdom; john.blaikley@manchester.ac.uk andrew.loudon@manchester.ac.uk David.Ray@ocdem.ox.ac.uk.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX37LE Oxford, United Kingdom.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jan 21; Vol. 117 (3), pp. 1543-1551. Date of Electronic Publication: 2020 Jan 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.
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  Data: <searchLink fieldCode="AU" term="%22Kitchen+GB%22">Kitchen GB</searchLink>; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.; Manchester Foundation Trust, Manchester Academic Health Science Centre, M13 9WL Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cunningham+PS%22">Cunningham PS</searchLink>; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Poolman+TM%22">Poolman TM</searchLink>; National Institute for Health Research, John Radcliffe Hospital, Oxford Biomedical Research Centre, OX3 9DU Oxford, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX37LE Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Iqbal+M%22">Iqbal M</searchLink>; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Maidstone+R%22">Maidstone R</searchLink>; National Institute for Health Research, John Radcliffe Hospital, Oxford Biomedical Research Centre, OX3 9DU Oxford, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX37LE Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Baxter+M%22">Baxter M</searchLink>; National Institute for Health Research, John Radcliffe Hospital, Oxford Biomedical Research Centre, OX3 9DU Oxford, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX37LE Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bagnall+J%22">Bagnall J</searchLink>; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Begley+N%22">Begley N</searchLink>; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Saer+B%22">Saer B</searchLink>; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hussell+T%22">Hussell T</searchLink>; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Matthews+LC%22">Matthews LC</searchLink>; Leeds Institute of Cancer and Pathology, Faculty of Medicine and Health, University of Leeds, LS9 7TF Leeds, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dockrell+DH%22">Dockrell DH</searchLink>; Department of Infection Medicine and Medical Research Council Centre for Inflammation Research, University of Edinburgh, EH16 4TJ Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Durrington+HJ%22">Durrington HJ</searchLink>; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.; Manchester Foundation Trust, Manchester Academic Health Science Centre, M13 9WL Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gibbs+JE%22">Gibbs JE</searchLink>; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Blaikley+JF%22">Blaikley JF</searchLink>; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom; john.blaikley@manchester.ac.uk andrew.loudon@manchester.ac.uk David.Ray@ocdem.ox.ac.uk.; Manchester Foundation Trust, Manchester Academic Health Science Centre, M13 9WL Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Loudon+AS%22">Loudon AS</searchLink>; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom; john.blaikley@manchester.ac.uk andrew.loudon@manchester.ac.uk David.Ray@ocdem.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Ray+DW%22">Ray DW</searchLink>; National Institute for Health Research, John Radcliffe Hospital, Oxford Biomedical Research Centre, OX3 9DU Oxford, United Kingdom; john.blaikley@manchester.ac.uk andrew.loudon@manchester.ac.uk David.Ray@ocdem.ox.ac.uk.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX37LE Oxford, United Kingdom.
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