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Diverse BRAF Gene Fusions Confer Resistance to EGFR-Targeted Therapy via Differential Modulation of BRAF Activity.

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Title: Diverse BRAF Gene Fusions Confer Resistance to EGFR-Targeted Therapy via Differential Modulation of BRAF Activity.
Authors: Stangl C; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.; Division of Molecular Oncology, Netherlands Cancer Institute, and Oncode Institute, Amsterdam, the Netherlands., Post JB; Molecular Cancer Research, Center for Molecular Medicine, and Oncode Institute, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands., van Roosmalen MJ; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.; Princess Máxima Center for Pediatric Oncology and Oncode Institute, Utrecht, the Netherlands., Hami N; Molecular Cancer Research, Center for Molecular Medicine, and Oncode Institute, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands., Verlaan-Klink I; Molecular Cancer Research, Center for Molecular Medicine, and Oncode Institute, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands., Vos HR; Molecular Cancer Research, Center for Molecular Medicine, and Oncode Institute, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands., van Es RM; Molecular Cancer Research, Center for Molecular Medicine, and Oncode Institute, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands., Koudijs MJ; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.; Center for Personalized Cancer Treatment, University Medical Center Utrecht, Utrecht, the Netherlands., Voest EE; Division of Molecular Oncology, Netherlands Cancer Institute, and Oncode Institute, Amsterdam, the Netherlands. wigardkloosterman@gmail.com e.voest@nki.nl., Snippert HJG; Molecular Cancer Research, Center for Molecular Medicine, and Oncode Institute, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands., Kloosterman WP; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands. wigardkloosterman@gmail.com e.voest@nki.nl.; Cyclomics, Utrecht, the Netherlands.; Frame Cancer Therapeutics, Amsterdam, the Netherlands.
Source: Molecular cancer research : MCR [Mol Cancer Res] 2020 Apr; Vol. 18 (4), pp. 537-548. Date of Electronic Publication: 2020 Jan 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101150042 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3125 (Electronic) Linking ISSN: 15417786 NLM ISO Abbreviation: Mol Cancer Res Subsets: MEDLINE
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  Data: Diverse BRAF Gene Fusions Confer Resistance to EGFR-Targeted Therapy via Differential Modulation of BRAF Activity.
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  Data: <searchLink fieldCode="AU" term="%22Stangl+C%22">Stangl C</searchLink>; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.; Division of Molecular Oncology, Netherlands Cancer Institute, and Oncode Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Post+JB%22">Post JB</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, and Oncode Institute, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Roosmalen+MJ%22">van Roosmalen MJ</searchLink>; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.; Princess Máxima Center for Pediatric Oncology and Oncode Institute, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hami+N%22">Hami N</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, and Oncode Institute, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Verlaan-Klink+I%22">Verlaan-Klink I</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, and Oncode Institute, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Vos+HR%22">Vos HR</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, and Oncode Institute, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Es+RM%22">van Es RM</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, and Oncode Institute, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Koudijs+MJ%22">Koudijs MJ</searchLink>; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.; Center for Personalized Cancer Treatment, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Voest+EE%22">Voest EE</searchLink>; Division of Molecular Oncology, Netherlands Cancer Institute, and Oncode Institute, Amsterdam, the Netherlands. wigardkloosterman@gmail.com e.voest@nki.nl.<br /><searchLink fieldCode="AU" term="%22Snippert+HJG%22">Snippert HJG</searchLink>; Molecular Cancer Research, Center for Molecular Medicine, and Oncode Institute, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kloosterman+WP%22">Kloosterman WP</searchLink>; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands. wigardkloosterman@gmail.com e.voest@nki.nl.; Cyclomics, Utrecht, the Netherlands.; Frame Cancer Therapeutics, Amsterdam, the Netherlands.
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